Protective effects of rutaecarpine in cardiac anaphylactic injury is mediated by CGRP

Hong Hui Yi, Wei Qing Rang, Pan Yue Deng, Chang Ping Hu, Gui Zhen Liu, Gui Shan Tan, Kang Ping Xu, Yuan Jian Li

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Previous investigations have indicated that rutaecarpine activates the vanilloid receptor to evoke calcitonin gene-related peptide (CGRP) release. CGRP has been shown to alleviate cardiac anaphylactic injury. In the present study, the effect of rutaecarpine on cardiac anaphylaxis was examined. Challenge of presensitized guinea-pig hearts with a specific antigen caused marked decreases in coronary flow (CF), left ventricular pressure (LVP) and its derivatives (± dp/dtmax), an increase in heart rate, and prolongation of the P-R interval. Rutaecarpine (0.3 or 1 μM) markedly increased the content of calcitonin gene-related peptide (CGRP) in the coronary effluent and decreased the content of tumor necrosis factor-α (TNF-α) in myocardial tissues concomitantly with a significant improvement of cardiac function and alleviation of the extension of the P-R interval. Rutaecarpine at the concentration of 1 μM also inhibited the sinus tachycardia. The protective effects of rutaecarpine on cardiac anaphylaxis were abolished by CGRP 8-37, a selective CGRP receptor antagonist. These results suggest that the protective effects of rutaecarpine on cardiac anaphylactic injury are related to inhibition of TNF-α production by stimulation of CGRP release.

Original languageEnglish
Pages (from-to)1135-1139
Number of pages5
JournalPlanta Medica
Volume70
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • Calcitonin gene-related peptide (CGRP)
  • Cardiac anaphylaxis
  • Guinea-pig
  • Rutaecarpine
  • Tumor necrosis factor-α (TNF-α)

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