Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury

Robert A. Swarm, Stanley W. Ashley, David I. Soybel, Frederick S. Ordway, Laurence Y. Cheung

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The protective effects of exogenous phospholipid on aspirin-induced gastric mucosal injury were examined in a canine chamber model which provided two separate segments of mucosa supplied by a single vascular pedicle. In each dog, one segment was treated with a suspension of surface-active phospholipid, similar in composition to that normally present in the gastric mucosa, whereas the other segment served as the control. Pretreatment of the test segments significantly prevented aspirin-induced disruption of the mucosal barrier as evidenced by an increase in potential difference and a decrease in acid back-diffusion and sodium ion and potassium ion flux. These findings were associated with a marked reduction in the degree of mucosal injury. Our results support the recent hypothesis that surface-active phospholipid plays an important role in gastric mucosal defense against the damaging effects to luminal acid.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalThe American Journal of Surgery
Volume153
Issue number1
DOIs
StatePublished - Jan 1987
Externally publishedYes

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