TY - JOUR
T1 - Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury
AU - Swarm, Robert A.
AU - Ashley, Stanley W.
AU - Soybel, David I.
AU - Ordway, Frederick S.
AU - Cheung, Laurence Y.
N1 - Funding Information:
From the Department of Surgery, Washlngton University School of Medl-clne, St LOUIS, MISSOURI Supported in part by the MedIcal Research Service of the Veterans AdmInistration, Washington, DC and by Grants ROI AM25998-07, R01 AM35191-01. and 2-T32-GM07602-07, National Institutes of Health, Bethesda, Maryland Requests for reprtnts should be addressed to Laurence Y Cheung, MD, Department of Surgery, Un1vers.Q of Kansas MedIcal Center, 39th and RaInbow Boulevard, Kansas City, Kansas 66103 Presented at the 27th Annual Meeting of the Society for Surgery of the Alimentary Tract, San Francisco, Caltfornia, May 20-21, 1988
PY - 1987/1
Y1 - 1987/1
N2 - The protective effects of exogenous phospholipid on aspirin-induced gastric mucosal injury were examined in a canine chamber model which provided two separate segments of mucosa supplied by a single vascular pedicle. In each dog, one segment was treated with a suspension of surface-active phospholipid, similar in composition to that normally present in the gastric mucosa, whereas the other segment served as the control. Pretreatment of the test segments significantly prevented aspirin-induced disruption of the mucosal barrier as evidenced by an increase in potential difference and a decrease in acid back-diffusion and sodium ion and potassium ion flux. These findings were associated with a marked reduction in the degree of mucosal injury. Our results support the recent hypothesis that surface-active phospholipid plays an important role in gastric mucosal defense against the damaging effects to luminal acid.
AB - The protective effects of exogenous phospholipid on aspirin-induced gastric mucosal injury were examined in a canine chamber model which provided two separate segments of mucosa supplied by a single vascular pedicle. In each dog, one segment was treated with a suspension of surface-active phospholipid, similar in composition to that normally present in the gastric mucosa, whereas the other segment served as the control. Pretreatment of the test segments significantly prevented aspirin-induced disruption of the mucosal barrier as evidenced by an increase in potential difference and a decrease in acid back-diffusion and sodium ion and potassium ion flux. These findings were associated with a marked reduction in the degree of mucosal injury. Our results support the recent hypothesis that surface-active phospholipid plays an important role in gastric mucosal defense against the damaging effects to luminal acid.
UR - http://www.scopus.com/inward/record.url?scp=0023088545&partnerID=8YFLogxK
U2 - 10.1016/0002-9610(87)90200-5
DO - 10.1016/0002-9610(87)90200-5
M3 - Article
C2 - 3799892
AN - SCOPUS:0023088545
SN - 0002-9610
VL - 153
SP - 48
EP - 53
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 1
ER -