Protective and Pathogenic Effects of Interferon Signaling during Pregnancy

Rebecca L. Casazza; Helen M. Lazear; Jonathan J. Miner

doi:10.1089/vim.2019.0076

Protective and Pathogenic Effects of Interferon Signaling during Pregnancy

Rebecca L. Casazza, Helen M. Lazear, Jonathan J. Miner

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus.

Original language	English
Pages (from-to)	3-11
Number of pages	9
Journal	Viral Immunology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1089/vim.2019.0076
State	Published - Jan 1 2020

Keywords

Zika virus
interferons
pregnancy
systemic lupus erythematosus

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10.1089/vim.2019.0076

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title = "Protective and Pathogenic Effects of Interferon Signaling during Pregnancy",

abstract = "Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus.",

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AU - Lazear, Helen M.

AU - Miner, Jonathan J.

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AB - Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus.

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KW - systemic lupus erythematosus

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Protective and Pathogenic Effects of Interferon Signaling during Pregnancy

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