TY - JOUR
T1 - Protection of ischemic myocardium by whole-body hypothermia after coronary artery occlusion in dogs
AU - Abendschein, Dana R.
AU - Tacker, Willis A.
AU - Babbs, Charles F.
N1 - Funding Information:
From the Biomedical Engineering Center and the Department Physiology and Pharmacology, School of Veterinary Medicine, Purdue University, West Lafayette, Ind. Received for publication Jan. 20, 1978. Accepted for publication May 5, 1978. Reprint requests: Dr. Willis A. Tacker, Biomedical Center, Purdue University, West Lafayette, Ind. 47907. *Dr. Abendschein was supported by a predoctoral American Heart Association, Indiana Affiliate,
PY - 1978/12
Y1 - 1978/12
N2 - Anesthetized dogs were cooled to a core body temperature of 26°C. or maintained at a body temperature of 37°C. during periods of 5 and 10 hours of LAD coronary artery occlusion. Subsequent macroscopic dehydrogenase enzyme mapping showed that ischemic injury was 25 per cent less after 5 hours of coronary occlusion and 20 per cent less after 10 hours of occlusion in hypothermic dogs than in normothermic controls. The heart rate and left ventricular minute work in hypothermic dogs decreased to roughly half the levels measured in normothermic animals, while left ventricular contractility was 10 to 40 per cent lower in hypothermic dogs than in normothermic dogs. However, cardiac index and left ventricular end-diastolic pressure were unchanged by whole-body cooling. Thus, hypothermia appeared to diminish the oxygen requirements of the ischemic myocardium without reducing the performance of the heart as a pump. Hypothermia may be useful as a therapeutic adjunct to myocardial revascularization or pharmacologic interventions.
AB - Anesthetized dogs were cooled to a core body temperature of 26°C. or maintained at a body temperature of 37°C. during periods of 5 and 10 hours of LAD coronary artery occlusion. Subsequent macroscopic dehydrogenase enzyme mapping showed that ischemic injury was 25 per cent less after 5 hours of coronary occlusion and 20 per cent less after 10 hours of occlusion in hypothermic dogs than in normothermic controls. The heart rate and left ventricular minute work in hypothermic dogs decreased to roughly half the levels measured in normothermic animals, while left ventricular contractility was 10 to 40 per cent lower in hypothermic dogs than in normothermic dogs. However, cardiac index and left ventricular end-diastolic pressure were unchanged by whole-body cooling. Thus, hypothermia appeared to diminish the oxygen requirements of the ischemic myocardium without reducing the performance of the heart as a pump. Hypothermia may be useful as a therapeutic adjunct to myocardial revascularization or pharmacologic interventions.
UR - http://www.scopus.com/inward/record.url?scp=0018128315&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(78)90010-8
DO - 10.1016/0002-8703(78)90010-8
M3 - Article
C2 - 717240
AN - SCOPUS:0018128315
SN - 0002-8703
VL - 96
SP - 772
EP - 780
JO - American heart journal
JF - American heart journal
IS - 6
ER -