Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus

James D. Brien, Soila Sukupolvi-Petty, Katherine L. Williams, Chia Ying Kao Lam, Michael A. Schmid, Syd Johnson, Eva Harris, Michael S. Diamond

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13 Scopus citations

Abstract

Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ~ 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.

Original languageEnglish
Pages (from-to)7747-7753
Number of pages7
JournalJournal of virology
Volume87
Issue number13
DOIs
StatePublished - Jul 1 2013

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    Brien, J. D., Sukupolvi-Petty, S., Williams, K. L., Lam, C. Y. K., Schmid, M. A., Johnson, S., Harris, E., & Diamond, M. S. (2013). Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus. Journal of virology, 87(13), 7747-7753. https://doi.org/10.1128/JVI.00327-13