Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

S. Sutcliffe, R. L. Nevin, R. Pakpahan, D. J. Elliott, S. R. Cole, A. M. De Marzo, C. A. Gaydos, W. B. Isaacs, W. G. Nelson, L. J. Sokoll, J. M. Zenilman, S. B. Cersovsky, E. A. Platz

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Abstract

Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P0.0001, 0.021, and 0.92, respectively). Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalBritish Journal of Cancer
Volume105
Issue number5
DOIs
StatePublished - Aug 23 2011
Externally publishedYes

Keywords

  • chlamydia
  • gonorrhoea
  • non-chlamydial
  • non-gonococcal urethritis
  • prostate cancer
  • prostate-specific antigen
  • sexually transmitted infections

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    Sutcliffe, S., Nevin, R. L., Pakpahan, R., Elliott, D. J., Cole, S. R., De Marzo, A. M., Gaydos, C. A., Isaacs, W. B., Nelson, W. G., Sokoll, L. J., Zenilman, J. M., Cersovsky, S. B., & Platz, E. A. (2011). Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration. British Journal of Cancer, 105(5), 602-605. https://doi.org/10.1038/bjc.2011.271