Prostate histoscanning true targeting guided prostate biopsy: initial clinical experience

Arjun Sivaraman, Rafael Sanchez-Salas, Eric Barret, Petr Macek, Pierre Validire, Marc Galiano, Francois Rozet, Xavier Cathelineau

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To evaluate the feasibility of prostate histoscanning true targeting (PHS-TT) guided transrectal ultrasound (TRUS) biopsy. Methods: This is a prospective, single center, pilot study performed during February 2013–September 2013. All consecutive patients planned for prostate biopsy were included in the study, and all the procedure was performed by a single surgeon aided by the specialized true targeting software. Initially, the patients underwent PHS to map the abnormal areas within the prostate that were ≥0.2 cm3. TRUS guided biopsies were performed targeting the abnormal areas with a specialized software. Additionally, routine bisextant biopsies were also taken. The final histopathology of the target cores was compared with the bisextant cores. Results: A total of 43 patients underwent combined ‘targeted PHS guided’ and ‘standard 12 core systematic’ biopsies. The mean volume of abnormal area detected by PHS is 4.3 cm3. The overall cancer detection rate was 46.5 % (20/43) with systemic cores and target cores detecting cancer in 44 % (19/43) and 26 % (11/43), respectively. The mean  % cancer/core length of the PHS-TT cores were significantly higher than the systematic cores (55.4 vs. 37.5 %. p < 0.05). In biopsy naïve patients, the cancer detection rate (43.7 % vs. 14.8 %. p = 0.06) and the cancer positivity of the cores (30.1 vs. 6.8 %. p < 0.01) of target cores were higher than those patients with prior biopsies. Conclusion: PHS-TT is feasible and can be an effective tool for real-time guidance of prostate biopsies.

Original languageEnglish
Pages (from-to)1475-1479
Number of pages5
JournalWorld Journal of Urology
Issue number10
StatePublished - Oct 30 2015


  • Prostate biopsy
  • Prostate cancer
  • Prostate histoscanning
  • TRUS biopsy
  • Target biopsy


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