TY - JOUR
T1 - Prostate cancer
T2 - Is it time to expand the research focus to early-life exposures?
AU - Sutcliffe, Siobhan
AU - Colditz, Graham A.
N1 - Funding Information:
The authors thank G. L. Andriole, A. M. De Marzo, E. A. Platz and C. G. Sutcliffe for valuable discussion related to this manuscript; P. Humphrey for generous provision of prostate histological images; and A. Ostendorf for assistance preparing figures. This manuscript was funded by the Barnes-Jewish Hospital Foundation. It makes use of data obtained from the Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan. RERF is a private, non-profit foundation funded by the Japanese Ministry of Health, Labour and Welfare and the US Department of Energy through the US National Academy of Sciences. The conclusions in this report are those of the authors and do not necessarily reflect the scientific judgment of RERF or its funding agencies.
PY - 2013/3
Y1 - 2013/3
N2 - Although the contribution of lifestyle and environment (non-genetic factors) to prostate carcinogenesis is indicated by international variation in prostate cancer occurrence and migration studies, no conclusive modifiable risk factors have yet been identified. One possible reason for this may be the dearth of epidemiological research on exposures experienced early in life, when the immature prostate may be more susceptible to carcinogenic exposures. In this Opinion article, we summarize the rationale for studying early-life exposures, describe the small body of early-life research and its associated challenges, and point to solutions for future research.
AB - Although the contribution of lifestyle and environment (non-genetic factors) to prostate carcinogenesis is indicated by international variation in prostate cancer occurrence and migration studies, no conclusive modifiable risk factors have yet been identified. One possible reason for this may be the dearth of epidemiological research on exposures experienced early in life, when the immature prostate may be more susceptible to carcinogenic exposures. In this Opinion article, we summarize the rationale for studying early-life exposures, describe the small body of early-life research and its associated challenges, and point to solutions for future research.
UR - http://www.scopus.com/inward/record.url?scp=84875421047&partnerID=8YFLogxK
U2 - 10.1038/nrc3434
DO - 10.1038/nrc3434
M3 - Review article
C2 - 23363989
AN - SCOPUS:84875421047
SN - 1474-175X
VL - 13
SP - 208
EP - 218
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 3
ER -