Prostaglandins and vascular tone in experimental obstructive nephropathy

We have tried to define both qualitatively and quantitatively the nature of the biochemical events, the factors controlling the synthesis and release of prostaglandins from the kidney, and the potential role for prostaglandins in controlling renal hemodynamics following unilateral ureteral obstruction and glycerol-induced acute renal failure. The latter model was chosen because one of the mechanisms invoked for the fall of GFR is intratubular obstruction.