TY - JOUR
T1 - Prostaglandin synthesis, inhibition, and intraocular pressure
AU - Podos, S. M.
AU - Becker, B.
AU - Kass, M. A.
PY - 1973/12/1
Y1 - 1973/12/1
N2 - Arachidonic acid, a precursor of prostaglandin E2, administered topically to rabbit and monkey eyes in concentrations of 0.2 to 20%, or intravenously to rabbits in doses of 10 to 20 mg., produced a significant elevation of intraocular pressure. A dose response relationship was demonstrated. Facility of outflow and anterior chamber aqueous protein were significantly higher in eyes treated topically with 2% arachidonic acid than fellow control eyes. These effects of arachidonic acid were similar to those of prostaglandin E applied topically. Pretreatment with indomethacin, given intraperitoneally in doses of 10 mg. per kg. or greater, or aspirin, as a 600 mg. suppository, prevented completely the elevation of intraocular pressure produced by two drops of 2% arachidonic acid applied to the eyes of rabbits. The elevation of anterior chamber aqueous protein induced by topically applied 2% arachidonic acid also was blocked by prior administration of indomethacin. Indomethacin and aspirin, inhibitors of prostaglandin synthesis from arachidonic acid, had no effect on the rise of intraocular pressure seen after instilling 5 μg. of prostaglandins E1 or E2.
AB - Arachidonic acid, a precursor of prostaglandin E2, administered topically to rabbit and monkey eyes in concentrations of 0.2 to 20%, or intravenously to rabbits in doses of 10 to 20 mg., produced a significant elevation of intraocular pressure. A dose response relationship was demonstrated. Facility of outflow and anterior chamber aqueous protein were significantly higher in eyes treated topically with 2% arachidonic acid than fellow control eyes. These effects of arachidonic acid were similar to those of prostaglandin E applied topically. Pretreatment with indomethacin, given intraperitoneally in doses of 10 mg. per kg. or greater, or aspirin, as a 600 mg. suppository, prevented completely the elevation of intraocular pressure produced by two drops of 2% arachidonic acid applied to the eyes of rabbits. The elevation of anterior chamber aqueous protein induced by topically applied 2% arachidonic acid also was blocked by prior administration of indomethacin. Indomethacin and aspirin, inhibitors of prostaglandin synthesis from arachidonic acid, had no effect on the rise of intraocular pressure seen after instilling 5 μg. of prostaglandins E1 or E2.
UR - http://www.scopus.com/inward/record.url?scp=0015832682&partnerID=8YFLogxK
M3 - Article
C2 - 4196439
AN - SCOPUS:0015832682
SN - 0020-9988
VL - 12
SP - 426
EP - 433
JO - Investigative ophthalmology
JF - Investigative ophthalmology
IS - 6
ER -