Prostaglandin release from vasculature by angiotensin II: Dissociation from lipolysis

P. Needleman, G. R. Marshall, J. R. Douglas

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Prostaglandin (PG) was released from the perfused splenic fat pad (with the spleen removed) by angiotensin (AII) and not by epinephrine or ACTH. The angiotensin antagonist, cysteine-8-AII blocked the AII induced PG release both in the spleen and the splenic fat pad. ACTH stimulated lipolysis from the rabbit spleen fat pad, but catecholamines and AII were ineffective. Thus, the release of PG from the rabbit splenic fat pad does not seem to require enhanced lipolysis nor do lipolytic agents cause the release of bioassayable PG.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalEuropean Journal of Pharmacology
Volume23
Issue number3
DOIs
StatePublished - Sep 1973

Keywords

  • Angiotensin
  • Cysteine-8-angiotensin II
  • Lipolysis
  • Splenic fat

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