Prostaglandin (PG) was released from the perfused splenic fat pad (with the spleen removed) by angiotensin (AII) and not by epinephrine or ACTH. The angiotensin antagonist, cysteine-8-AII blocked the AII induced PG release both in the spleen and the splenic fat pad. ACTH stimulated lipolysis from the rabbit spleen fat pad, but catecholamines and AII were ineffective. Thus, the release of PG from the rabbit splenic fat pad does not seem to require enhanced lipolysis nor do lipolytic agents cause the release of bioassayable PG.
- Cysteine-8-angiotensin II
- Splenic fat