Prostacyclin receptor regulation---from transcription to trafficking

C. Midgett, J. Stitham, K. A. Martin, J. Hwa

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


The prostacyclin receptor (IP - International Union of Pharmacology nomenclature) is a member of the seven transmembrane G-protein coupled receptor (GPCR) superfamily. Recent concerns with selective and non-selective COX-1/COX-2 inhibition have exposed an important cardioprotective role for IP in preventing atherothrombosis. Receptor dysfunction (genetic variants) or reduced signaling (COX-2 inhibition) in high cardiovascular risk patients leads to increased cardiovascular events. These clinical observations have also been confirmed genetically by mouse knockout studies. Thus, receptor regulation is paramount in ensuring correct function in the prevention of atherothrombosis. This review summarizes recent literature on how this important receptor is regulated, from transcription to transport (to and from the membrane surface). These regulatory processes are critical in ensuring that IP receptors are adequately expressed and functional on the cell surface.

Original languageEnglish
Pages (from-to)517-527
Number of pages11
JournalCurrent Molecular Medicine
Issue number7
StatePublished - 2011


  • Activation
  • Desensitization
  • Dimerization
  • Internalization
  • Prostacyclin receptor
  • Transcriptional regulation


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