TY - JOUR
T1 - Prospective study of smoking and the risk of breast cancer
AU - London, Stephanie J.
AU - Colditz, Graham A.
AU - Stampfer, Meir J.
AU - Willett, Walter C.
AU - Rosner, Bernard A.
AU - Speizer, Frank E.
N1 - Funding Information:
Received May 16, 1989; revised July 28, 1989; accepted August 8, 1989. Supported by Public Health Service grants CA-40356 and CA-40935 from the National Cancer Institute, and an Institutional National Research Service Award (CA-09001) from the National Institutes of Health, Department of Health and Human Services. S. J. London, M. J. Stampfer, W. C. Willett (Department of Epidemiology), W. C. Willett (Department of Nutrition), Harvard School of Public Health, Boston, MA. G. A. Colditz, M. J. Stampfer, W. C. Willett, F. E. Speizer (Channing Laboratory), B. A. Rosner (Departments of Medicine and Preventive Medicine), Harvard Medical School and Brigham and Women's Hospital, Boston, MA. We thank the participants in the Nurses' Health Study for their continuing cooperation, and Gail Cammarata, Suewei Chiang, Karen Corsano, Barbara Egan, Doreen Hurd, Mark Shneyder, Steven Stuart, Marion McPhee, and Donna Vincent for their expert help. * Correspondence to: Dr. Walter C. Willett, Channing Laboratory, 180 Longwood Ave., Boston, MA 02115.
PY - 1989/11/1
Y1 - 1989/11/1
N2 - In 1976, 117, 557 women in the United States aged 30-55 years and without a history of cancer provided detailed information on current smoking habits. By 1986, 1,788 cases of breast cancer had been documented during 1,133,682 person-years. There was no association between current smoking and risk of breast cancer (multivariate-adjusted relative risk for smokers of ≥25 cigarettes/day compared to nonsmokers: 1.02, 95% confidence interval, 0.86-1.22). Past smoking also was unrelated to breast cancer risk (relative risk, 1.08; 95% confidence interval, 0.96-1.20). The results did not differ by menopausal status. Tumor size and the presence of nodal metastases were unrelated to smoking. Smoking was weakly associated with estrogen receptor-positive tumors (relative risk for smokers of ≥25 cigarettes/day compared with never smokers, 1.38; 95% confidence interval, 1.04-1.84), but there was no dose-response relationship across categories of current smoking. These results suggest that smoking and breast cancer are not materially related [J Natl Cancer Inst 81:1625-1631, 1989].
AB - In 1976, 117, 557 women in the United States aged 30-55 years and without a history of cancer provided detailed information on current smoking habits. By 1986, 1,788 cases of breast cancer had been documented during 1,133,682 person-years. There was no association between current smoking and risk of breast cancer (multivariate-adjusted relative risk for smokers of ≥25 cigarettes/day compared to nonsmokers: 1.02, 95% confidence interval, 0.86-1.22). Past smoking also was unrelated to breast cancer risk (relative risk, 1.08; 95% confidence interval, 0.96-1.20). The results did not differ by menopausal status. Tumor size and the presence of nodal metastases were unrelated to smoking. Smoking was weakly associated with estrogen receptor-positive tumors (relative risk for smokers of ≥25 cigarettes/day compared with never smokers, 1.38; 95% confidence interval, 1.04-1.84), but there was no dose-response relationship across categories of current smoking. These results suggest that smoking and breast cancer are not materially related [J Natl Cancer Inst 81:1625-1631, 1989].
UR - http://www.scopus.com/inward/record.url?scp=0024451785&partnerID=8YFLogxK
U2 - 10.1093/jnci/81.21.1625
DO - 10.1093/jnci/81.21.1625
M3 - Article
C2 - 2795691
AN - SCOPUS:0024451785
SN - 0027-8874
VL - 81
SP - 1625
EP - 1631
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 21
ER -