TY - JOUR
T1 - Prospective study of oral contraceptive use and risk of breast cancer in women
AU - Romieu, Isabelle
AU - Willett, Walter C.
AU - Colditz, Graham A.
AU - Stampfer, Meir J.
AU - Rosner, Bernard
AU - Hennekens, Charles H.
AU - Speizer, Frank E.
N1 - Funding Information:
Received January 23, 1989; revised May 31, 1989; accepted June 19, 1989. Supported by Public Health Service grants CA-40935 and CA-40356 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. I. Romieu, W. C. Willett, G. A. Colditz, M. J. Stampfer, B. Rosner, C. H. Hennekens, F. E. Speizer (Channing Laboratory, Department of Medicine), B. Rosner (Department of Preventive Medicine), Harvard Medical School, Boston, MA. I. Romieu, W. C. Willett, G. A. Colditz, M. J. Stampfer, B. Rosner, C. H. Hennekens, F. E. Speizer, Brigham and Women's Hospital, Boston, MA. W. C. Willett (Department of Epidemiology and Nutrition), M. J. Stampfer (Department of Epidemiology), Harvard School of Public Health, Boston, MA. We thank the registered nurses who made this study possible and Gary Chase, Sue-Wei Chiang, Karen Corsano, Barbara Egan, Lori Egan, David Dysert, and-Mark Schneyder, who assisted in the research. *Correspondence to: Dr. W. C. Willett, Channing Laboratory, Department of Medicine, Harvard Medical School, 180 Longwood Ave., Boston, MA 02115.
PY - 1989/9/6
Y1 - 1989/9/6
N2 - In 1976, 118,273 female nurses 30-55 years of age with no history of cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years of follow-up, we had documented 1,799 newly diagnosed cases of breast cancer. Compared with the risk of breast cancer for nonusers of oral contraceptives, the multivariate relative risks were 1.07 (95% confidence interval, 0.97-1.19) for all users, 1.06 (95% confidence interval, 0.96-1.18) for past users, and 1.53 (95% confidence interval, 1.06-2.19) for current users-women who used oral contraceptives up to 2 years before diagnosis of breast cancer. We conclude that overall past use of oral contraceptives is not associated with a substantial increase in the risk of breast cancer. Although we did not find women who used oral contraceptives before the first pregnancy to have an increased risk of breast cancer, the number of women who used oral contraceptives for a long duration in early reproductive life was too small to permit firm conclusions regarding the risk in this subgroup. [J Natl Cancer Inst 81:1313-1321, 1989].
AB - In 1976, 118,273 female nurses 30-55 years of age with no history of cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years of follow-up, we had documented 1,799 newly diagnosed cases of breast cancer. Compared with the risk of breast cancer for nonusers of oral contraceptives, the multivariate relative risks were 1.07 (95% confidence interval, 0.97-1.19) for all users, 1.06 (95% confidence interval, 0.96-1.18) for past users, and 1.53 (95% confidence interval, 1.06-2.19) for current users-women who used oral contraceptives up to 2 years before diagnosis of breast cancer. We conclude that overall past use of oral contraceptives is not associated with a substantial increase in the risk of breast cancer. Although we did not find women who used oral contraceptives before the first pregnancy to have an increased risk of breast cancer, the number of women who used oral contraceptives for a long duration in early reproductive life was too small to permit firm conclusions regarding the risk in this subgroup. [J Natl Cancer Inst 81:1313-1321, 1989].
UR - http://www.scopus.com/inward/record.url?scp=0024453293&partnerID=8YFLogxK
U2 - 10.1093/jnci/81.17.1313
DO - 10.1093/jnci/81.17.1313
M3 - Article
C2 - 2769784
AN - SCOPUS:0024453293
SN - 0027-8874
VL - 81
SP - 1313
EP - 1321
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 17
ER -