Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

Vesna Jevtovic-Todorovic; David F. Wozniak; Sarah Powell; John W. Olney

doi:10.1016/S0006-8993(01)02800-1

Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

Vesna Jevtovic-Todorovic
, David F. Wozniak
, Sarah Powell
, John W. Olney

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents -propofol and sodium thiopental - protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Brain Research
Volume	913
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02800-1
State	Published - Sep 21 2001

Keywords

Adult rat
GABAergic agent
NMDA antagonist
Neuroprotection
Neurotoxicity

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10.1016/S0006-8993(01)02800-1

Cite this

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title = "Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex",

abstract = "N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents -propofol and sodium thiopental - protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.",

keywords = "Adult rat, GABAergic agent, NMDA antagonist, Neuroprotection, Neurotoxicity",

author = "Vesna Jevtovic-Todorovic and Wozniak, \{David F.\} and Sarah Powell and Olney, \{John W.\}",

note = "Funding Information: We thank J. Labruyere and A. Nardi for technical assistance. Supported in part by NIH grants AG 11355 and DA05072, FAER/ABBOTT New investigator Award (V.J.T.), Career Development Award (NIH) DA00406 (V.J.T.) and a NARSAD 2000 Toulmin Distinguished Investigator Award (J.W.O.).",

year = "2001",

month = sep,

day = "21",

doi = "10.1016/S0006-8993(01)02800-1",

language = "English",

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pages = "185--189",

journal = "Brain Research",

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T1 - Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

AU - Jevtovic-Todorovic, Vesna

AU - Wozniak, David F.

AU - Powell, Sarah

AU - Olney, John W.

N1 - Funding Information: We thank J. Labruyere and A. Nardi for technical assistance. Supported in part by NIH grants AG 11355 and DA05072, FAER/ABBOTT New investigator Award (V.J.T.), Career Development Award (NIH) DA00406 (V.J.T.) and a NARSAD 2000 Toulmin Distinguished Investigator Award (J.W.O.).

PY - 2001/9/21

Y1 - 2001/9/21

N2 - N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents -propofol and sodium thiopental - protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.

AB - N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents -propofol and sodium thiopental - protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.

KW - Adult rat

KW - GABAergic agent

KW - NMDA antagonist

KW - Neuroprotection

KW - Neurotoxicity

UR - https://www.scopus.com/pages/publications/0035929510

U2 - 10.1016/S0006-8993(01)02800-1

DO - 10.1016/S0006-8993(01)02800-1

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AN - SCOPUS:0035929510

SN - 0006-8993

VL - 913

SP - 185

EP - 189

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

Abstract

Keywords

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