TY - JOUR
T1 - Prophylactic negative-pressure wound therapy after cesarean is associated with reduced risk of surgical site infection
T2 - a systematic review and meta-analysis
AU - Yu, Lulu
AU - Kronen, Ryan J.
AU - Simon, Laura E.
AU - Stoll, Carolyn R.T.
AU - Colditz, Graham A.
AU - Tuuli, Methodius G.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Objective: The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery. Data Sources: We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. Study Eligibility Criteria: We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery. Study Appraisal and Synthesis Methods: The primary outcome was surgical site infection after cesarean delivery. Secondary outcomes were composite wound complications, wound dehiscence, wound seroma, endometritis, and hospital readmission. Heterogeneity was assessed using Higgin's I2. Relative risks with 95% confidence intervals were calculated using random-effects models. Results: Six randomized controlled trials and 3 cohort studies in high-risk mostly obese women met inclusion criteria and were included in the meta-analysis. Six were full-text articles, 2 published abstracts, and 1 report of trial results in ClinicalTrials.gov. Studies were also heterogeneous in the patients included and type of negative-pressure wound therapy device. The risk of surgical site infection was significantly lower with the use of prophylactic negative-pressure wound therapy compared with standard wound dressing (7 studies: pooled risk ratio, 0.45; 95% confidence interval, 0.31–0.66; adjusted risk ratio, –6.0%, 95% confidence interval, –10.0% to –3.0%; number needed to treat, 17, 95% confidence interval, 10–34). There was no evidence of significant statistical heterogeneity (I2 = 9.9%) or publication bias (Egger P =.532). Of the secondary outcomes, only composite wound complications were significantly reduced in patients receiving prophylactic negative-pressure wound therapy compared with standard dressing (9 studies: pooled risk ratio, 0.68, 95% confidence interval, 0.49–0.94). Conclusion: Studies on the effectiveness of prophylactic negative-pressure wound therapy at cesarean delivery are heterogeneous but suggest a reduction in surgical site infection and overall wound complications. Larger definitive trials are needed to clarify the clinical utility of prophylactic negative-pressure wound therapy after cesarean delivery.
AB - Objective: The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery. Data Sources: We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. Study Eligibility Criteria: We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery. Study Appraisal and Synthesis Methods: The primary outcome was surgical site infection after cesarean delivery. Secondary outcomes were composite wound complications, wound dehiscence, wound seroma, endometritis, and hospital readmission. Heterogeneity was assessed using Higgin's I2. Relative risks with 95% confidence intervals were calculated using random-effects models. Results: Six randomized controlled trials and 3 cohort studies in high-risk mostly obese women met inclusion criteria and were included in the meta-analysis. Six were full-text articles, 2 published abstracts, and 1 report of trial results in ClinicalTrials.gov. Studies were also heterogeneous in the patients included and type of negative-pressure wound therapy device. The risk of surgical site infection was significantly lower with the use of prophylactic negative-pressure wound therapy compared with standard wound dressing (7 studies: pooled risk ratio, 0.45; 95% confidence interval, 0.31–0.66; adjusted risk ratio, –6.0%, 95% confidence interval, –10.0% to –3.0%; number needed to treat, 17, 95% confidence interval, 10–34). There was no evidence of significant statistical heterogeneity (I2 = 9.9%) or publication bias (Egger P =.532). Of the secondary outcomes, only composite wound complications were significantly reduced in patients receiving prophylactic negative-pressure wound therapy compared with standard dressing (9 studies: pooled risk ratio, 0.68, 95% confidence interval, 0.49–0.94). Conclusion: Studies on the effectiveness of prophylactic negative-pressure wound therapy at cesarean delivery are heterogeneous but suggest a reduction in surgical site infection and overall wound complications. Larger definitive trials are needed to clarify the clinical utility of prophylactic negative-pressure wound therapy after cesarean delivery.
KW - antibiotics
KW - cesarean delivery
KW - dehiscence
KW - endometritis
KW - hospital readmission
KW - meta-analysis
KW - prophylactic negative-pressure wound therapy
KW - seroma
KW - surgical site infection
UR - http://www.scopus.com/inward/record.url?scp=85034827022&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2017.09.017
DO - 10.1016/j.ajog.2017.09.017
M3 - Review article
C2 - 28951263
AN - SCOPUS:85034827022
SN - 0002-9378
VL - 218
SP - 200-210.e1
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 2
ER -