TY - JOUR
T1 - Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus
AU - Yanowitz, Toby Debra
AU - Baker, Robyn Wyman
AU - Brozanski, Beverly Sobchak
N1 - Funding Information:
Supported by NIH K23 HD01317
PY - 2003/6
Y1 - 2003/6
N2 - Objective: To determine the relative risk of severe intraventricular hemorrhage (IVH) between two very early indomethacin treatment strategies. Study Design: Retrospective chart review <29 weeks gestation and <1350 g who received either indomethacin prophylaxis or very early echocardiography with indomethacin treatment only if the ductus arteriosus was patent. Results: A total of one hundred and two infants received prophylactic indomethacin (pINDO). Echochardiography was performed on 158 infants, whom 117 received indomethacin. Infants receiving pINDO had lower gestational age, but similar birth weight, gender, race, antenatal steroid exposure, delivery mode, Apgar scores, and need for resuscitation as infants evaluated by echocardiography. Grades III to IV IVH was observed less frequently in infants who received pINDO (OR 0.27, 95% CI 0.10 to 0.77, p = 0.014). Frequency of side effects and recurrent patent ductus arteriosus did not differ between treatment groups. Conclusion: pINDO reduces severe IVH when compared to an early echocardiography strategy.
AB - Objective: To determine the relative risk of severe intraventricular hemorrhage (IVH) between two very early indomethacin treatment strategies. Study Design: Retrospective chart review <29 weeks gestation and <1350 g who received either indomethacin prophylaxis or very early echocardiography with indomethacin treatment only if the ductus arteriosus was patent. Results: A total of one hundred and two infants received prophylactic indomethacin (pINDO). Echochardiography was performed on 158 infants, whom 117 received indomethacin. Infants receiving pINDO had lower gestational age, but similar birth weight, gender, race, antenatal steroid exposure, delivery mode, Apgar scores, and need for resuscitation as infants evaluated by echocardiography. Grades III to IV IVH was observed less frequently in infants who received pINDO (OR 0.27, 95% CI 0.10 to 0.77, p = 0.014). Frequency of side effects and recurrent patent ductus arteriosus did not differ between treatment groups. Conclusion: pINDO reduces severe IVH when compared to an early echocardiography strategy.
UR - http://www.scopus.com/inward/record.url?scp=0037804118&partnerID=8YFLogxK
U2 - 10.1038/sj.jp.7210893
DO - 10.1038/sj.jp.7210893
M3 - Article
C2 - 12774141
AN - SCOPUS:0037804118
SN - 0743-8346
VL - 23
SP - 317
EP - 322
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -