TY - JOUR
T1 - Prophylactic antibiotics for excision of premalignant vulvar lesions
T2 - A pilot randomized controlled trial
AU - Mullen, Mary
AU - Grither, Whitney R.
AU - Millimet, Hannah
AU - Mutch, David
AU - Hagemann, Andrea
AU - McCourt, Carolyn
AU - Powell, Matthew
AU - H.Thaker, Premal
AU - Khabele, Dineo
AU - Kuroki, Lindsay M.
N1 - Publisher Copyright:
© 2024
PY - 2024/10
Y1 - 2024/10
N2 - No prospective data have been described to inform guidelines on antibiotic prophylaxis for partial vulvectomies. Thus, we conducted a single-center, pilot, double-blind randomized controlled trial to assess the effectiveness of prophylactic antibiotics to prevent wound complications after partial vulvectomies. Patients were randomly assigned 1:1 to preoperative antibiotics or no preoperative antibiotics. The primary outcome of 30-day postoperative wound complications occurred in 31 (62 %) of all patients, with no differences between groups. The most common wound complications were superficial separation (54.2 % antibiotic prophylaxis vs. 65.3 % no prophylaxis, p = 0.37) and surgical site infection (0 % antibiotic prophylaxis vs 7.7 % no prophylaxis, p = 0.49). However, this study was limited by differences in patient characteristics between the groups. This study provides data to perform power calculations for a trial examining the effect of preoperative antibiotics on surgical site infection.
AB - No prospective data have been described to inform guidelines on antibiotic prophylaxis for partial vulvectomies. Thus, we conducted a single-center, pilot, double-blind randomized controlled trial to assess the effectiveness of prophylactic antibiotics to prevent wound complications after partial vulvectomies. Patients were randomly assigned 1:1 to preoperative antibiotics or no preoperative antibiotics. The primary outcome of 30-day postoperative wound complications occurred in 31 (62 %) of all patients, with no differences between groups. The most common wound complications were superficial separation (54.2 % antibiotic prophylaxis vs. 65.3 % no prophylaxis, p = 0.37) and surgical site infection (0 % antibiotic prophylaxis vs 7.7 % no prophylaxis, p = 0.49). However, this study was limited by differences in patient characteristics between the groups. This study provides data to perform power calculations for a trial examining the effect of preoperative antibiotics on surgical site infection.
KW - Antibiotic prophylaxis
KW - Premalignant vulvar lesions
KW - Surgical excision
KW - Wound complications
UR - http://www.scopus.com/inward/record.url?scp=85201072576&partnerID=8YFLogxK
U2 - 10.1016/j.gore.2024.101476
DO - 10.1016/j.gore.2024.101476
M3 - Article
C2 - 39229484
AN - SCOPUS:85201072576
SN - 2352-5789
VL - 55
JO - Gynecologic Oncology Reports
JF - Gynecologic Oncology Reports
M1 - 101476
ER -