Prompt initiation of art with therapeutic food is associated with improved outcomes in HIV-infected malawian children with malnutrition

Maria H. Kim, Carrie Cox, Anjalee Dave, Heather R. Draper, Mark Kabue, Gordon E. Schutze, Saeed Ahmed, Peter N. Kazembe, Mark W. Kline, Mark Manary

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

This retrospective observational study of 140 HIVinfected children with uncomplicated malnutrition in urban Malawi tested the hypothesis that initiation of antiretroviral therapy (ART) within 21 days of outpatient therapeutic feeding (prompt ART) improved clinical outcomes. Children receiving prompt ART were more likely to recover nutritionally (86% vs. 60%, P < 0.01) and had higher rates of weight gain (3.6 vs. 1.6 g/k/day; P = 0.02). Logistic regression modeling found prompt ART was associated with increased likelihood of nutritional recovery (odds ratio: 5.4, 95% confidence interval: 2.0 to 14.5). This suggests that prompt ART is associated with improved outcomes in HIV-infected Malawian children with uncomplicated malnutrition.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Antiretroviral therapy
  • Children
  • HIV
  • Malnutrition

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