Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab

Helen Hwang, Jiayi Huang, Karam Khaddour, Omar H. Butt, George Ansstas, Jie Chen, Ruth G.N. Katumba, Albert Kim, Eric C. Leuthardt, Jian Campian

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Despite the improved understanding of the molecular and genetic heterogeneity of glioblastoma, there is still an unmet need for better therapeutics, as treatment approaches have remained unchanged in recent years. Research into the role of the immune microenvironment has generated enthusiasm for testing immunotherapy (specifically, immune checkpoint inhibitors). However, to date, trials of immunotherapy in glioblastoma have not demonstrated a survival advantage. Combination approaches aimed at optimally inducing response to immune checkpoint inhibitors with radiotherapy are currently being investigated. Herein, the authors describe their experience of the potential benefit and clinical outcomes of using combination pembrolizumab (an immune checkpoint inhibitor) and laser interstitial thermal therapy in a case series of patients with recurrent IDH-wild-type glioblastoma.

Original languageEnglish
Article numberCNS81
JournalCNS oncology
Volume11
Issue number1
DOIs
StatePublished - Mar 2022

Keywords

  • glioblastoma
  • immune checkpoint inhibitors
  • immunotherapy
  • laser interstitial thermal therapy
  • pembrolizumab

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