TY - JOUR
T1 - Prolonged procoagulant activity on overstretch-injured coronary arteries in pigs
AU - Abendschein, D. R.
AU - Yang, L. Y.
AU - Chun, J.
AU - Cho, D.
AU - Scherrer, D.
AU - ST. Pierre, J.
PY - 2003/4
Y1 - 2003/4
N2 - This study was designed to assess the time course and nature of the vascular procoagulant response after 1.5-fold balloon overstretch injury of the coronary arteries in pigs. Arteries were excised for chromogenic assay of bound factor (F)Xa and thrombin at 24 h, 3 days, 1 week, or 2 weeks after injury. FXa at the site of injury remained elevated for 1 week (4.9±5.9 μg cm -2, n=10), compared with non-injured control arteries (0.4±0.2 μg cm -2, n=18, P=0.00025), while thrombin was increased only at 24 h. Tissue factor protein was abundant in non-injured coronaries (10±6ngp μg -1 total protein, n=9) and levels were unchanged by injury (13±11 ng μg -1, n=6) or 24-h administration of tissue factor pathway inhibitor (16±6ng μg -1, n=6). Persistent tissue factor-mediated procoagulant activity may explain the need for prolonged anticoagulation to attenuate neointimal formation after balloon-induced coronary injury.
AB - This study was designed to assess the time course and nature of the vascular procoagulant response after 1.5-fold balloon overstretch injury of the coronary arteries in pigs. Arteries were excised for chromogenic assay of bound factor (F)Xa and thrombin at 24 h, 3 days, 1 week, or 2 weeks after injury. FXa at the site of injury remained elevated for 1 week (4.9±5.9 μg cm -2, n=10), compared with non-injured control arteries (0.4±0.2 μg cm -2, n=18, P=0.00025), while thrombin was increased only at 24 h. Tissue factor protein was abundant in non-injured coronaries (10±6ngp μg -1 total protein, n=9) and levels were unchanged by injury (13±11 ng μg -1, n=6) or 24-h administration of tissue factor pathway inhibitor (16±6ng μg -1, n=6). Persistent tissue factor-mediated procoagulant activity may explain the need for prolonged anticoagulation to attenuate neointimal formation after balloon-induced coronary injury.
KW - Angioplasty
KW - Anticoagulation
KW - Restenosis
KW - Tissue factor
UR - http://www.scopus.com/inward/record.url?scp=0142166252&partnerID=8YFLogxK
U2 - 10.1046/j.1538-7836.2003.00100.x
DO - 10.1046/j.1538-7836.2003.00100.x
M3 - Article
C2 - 12871423
AN - SCOPUS:0142166252
VL - 1
SP - 836
EP - 842
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
SN - 1538-7933
IS - 4
ER -