Prolonged maintenance of endocochlear potential by vascular perfusion with media devoid of oxygen carriers

T. Kobayashi, M. Rokugo, D. C. Marcus, T. H. Comegys, R. Thalmann

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A method is described for maintaining the cochlear potentials of the guinea pig via arterial perfusion of the surviving inner ear with an artificial medium devoid of oxygen carriers or oncotic agents. The endocochlear potential (EP) can be maintained at a normal level for periods in excess of 5 h; the responses of the EP to anoxia and to furosemide closely approximate those seen in the intact animal. This preparation may represent a simplified method for carrying out selected arterial perfusion experiments in the surviving inner ear.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalArchives of Oto-Rhino-Laryngology
Volume239
Issue number3
DOIs
StatePublished - Apr 1 1984

Keywords

  • Endocochlear potential
  • Vascular perfusion

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