Proliferation of lamellar whorls in arcuate neurons of the hypothalamus of castrated and morphine-treated male rats

M. T. Price, J. W. Olney, T. J. Cicero

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28 Scopus citations

Abstract

A comprehensive ultrastructural examination of one cross-sectional level (middle 1/3) of the arcuate nucleus of the hypothalamus (AH) of male rats several weeks after castration or after two weeks of morphine treatment confirmed a marked increase in lamellar whorls of endoplasmic reticulum in AH neurons in each group. A comparable incidence of AH whorls was not detected in rats treated with lactose, those treated for only 1-3 days with morphine, or in those given testosterone plus morphine for 2 weeks. It is postulated that the testosterone deficiency following either castration or chronic morphine treatment stimulated the observed increase in AH whorls. A close correspondence was noted between the distribution within the AH of neurons containing whorls and those reported by others to contain luteinizing hormone releasing hormone (LH-RH). The possibility that whorls may be a marker for hypothalamic neurons which play a role in the LH-RH regulatory system warrants further consideration.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalCell and Tissue Research
Volume171
Issue number3
DOIs
StatePublished - Aug 1 1976

Keywords

  • Arcuate nucleus
  • LH-RH
  • Lamellar whorls
  • Morphine
  • Testosterone

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