Prolactin-Secreting Tumors and Hypogonadism in Men

B. A. Schainker; T. J. Cicero; Bruno Ambrosi; Roberto Elli; Maria Gaggini; Maurizio Rondena; Giovanni Faglia; J. H. Tyson

doi:10.1056/NEJM197903083001013

Prolactin-Secreting Tumors and Hypogonadism in Men

B. A. Schainker
, T. J. Cicero
, Bruno Ambrosi
, Roberto Elli
, Maria Gaggini
, Maurizio Rondena
, Giovanni Faglia
, J. H. Tyson

Department of Psychiatry

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Abstract

To the Editor: We commend Carter et al.¹ for a well designed study indicating reversal of hypogonadism, impotence and decreased libido in men with prolactin-secreting pituitary tumors after bromocriptine pharmacotherapy. We suggest the possible alternative use of naloxone to suppress serum prolactin while simultaneously stimulating the hypothalamic-pituitary-gonadal axis centrally. Opiate narcotics and opioid peptides acutely depress serum luteinizing hormone and elevate serum prolactin in rat and man.² ³ ⁴ ⁵ Conversely, the narcotic antagonists naloxone and naltrexone have opposite effects.⁶ ⁷ ⁸ This phenomenon has been extensively studied in the male rat and apparently reflects normal suprasellar modulation of the hypothalamic-pituitary-gonadal axis by endogenous opioid.

Original language	English
Pages (from-to)	563-564
Number of pages	2
Journal	New England Journal of Medicine
Volume	300
Issue number	10
DOIs	https://doi.org/10.1056/NEJM197903083001013
State	Published - Mar 8 1979

Access to Document

10.1056/NEJM197903083001013

Cite this

@article{4092668aac424a5986df2e95aba96e70,

title = "Prolactin-Secreting Tumors and Hypogonadism in Men",

abstract = "To the Editor: We commend Carter et al.1 for a well designed study indicating reversal of hypogonadism, impotence and decreased libido in men with prolactin-secreting pituitary tumors after bromocriptine pharmacotherapy. We suggest the possible alternative use of naloxone to suppress serum prolactin while simultaneously stimulating the hypothalamic-pituitary-gonadal axis centrally. Opiate narcotics and opioid peptides acutely depress serum luteinizing hormone and elevate serum prolactin in rat and man.2 3 4 5 Conversely, the narcotic antagonists naloxone and naltrexone have opposite effects.6 7 8 This phenomenon has been extensively studied in the male rat and apparently reflects normal suprasellar modulation of the hypothalamic-pituitary-gonadal axis by endogenous opioid.",

author = "Schainker, \{B. A.\} and Cicero, \{T. J.\} and Bruno Ambrosi and Roberto Elli and Maria Gaggini and Maurizio Rondena and Giovanni Faglia and Tyson, \{J. H.\}",

year = "1979",

month = mar,

day = "8",

doi = "10.1056/NEJM197903083001013",

language = "English",

volume = "300",

pages = "563--564",

journal = "New England Journal of Medicine",

issn = "0028-4793",

number = "10",

}

TY - JOUR

T1 - Prolactin-Secreting Tumors and Hypogonadism in Men

AU - Schainker, B. A.

AU - Cicero, T. J.

AU - Ambrosi, Bruno

AU - Elli, Roberto

AU - Gaggini, Maria

AU - Rondena, Maurizio

AU - Faglia, Giovanni

AU - Tyson, J. H.

PY - 1979/3/8

Y1 - 1979/3/8

N2 - To the Editor: We commend Carter et al.1 for a well designed study indicating reversal of hypogonadism, impotence and decreased libido in men with prolactin-secreting pituitary tumors after bromocriptine pharmacotherapy. We suggest the possible alternative use of naloxone to suppress serum prolactin while simultaneously stimulating the hypothalamic-pituitary-gonadal axis centrally. Opiate narcotics and opioid peptides acutely depress serum luteinizing hormone and elevate serum prolactin in rat and man.2 3 4 5 Conversely, the narcotic antagonists naloxone and naltrexone have opposite effects.6 7 8 This phenomenon has been extensively studied in the male rat and apparently reflects normal suprasellar modulation of the hypothalamic-pituitary-gonadal axis by endogenous opioid.

AB - To the Editor: We commend Carter et al.1 for a well designed study indicating reversal of hypogonadism, impotence and decreased libido in men with prolactin-secreting pituitary tumors after bromocriptine pharmacotherapy. We suggest the possible alternative use of naloxone to suppress serum prolactin while simultaneously stimulating the hypothalamic-pituitary-gonadal axis centrally. Opiate narcotics and opioid peptides acutely depress serum luteinizing hormone and elevate serum prolactin in rat and man.2 3 4 5 Conversely, the narcotic antagonists naloxone and naltrexone have opposite effects.6 7 8 This phenomenon has been extensively studied in the male rat and apparently reflects normal suprasellar modulation of the hypothalamic-pituitary-gonadal axis by endogenous opioid.

UR - https://www.scopus.com/pages/publications/0018362814

U2 - 10.1056/NEJM197903083001013

DO - 10.1056/NEJM197903083001013

M3 - Letter

C2 - 763260

AN - SCOPUS:0018362814

SN - 0028-4793

VL - 300

SP - 563

EP - 564

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 10

ER -

Prolactin-Secreting Tumors and Hypogonadism in Men

Abstract

Access to Document

Other files and links

Fingerprint

Cite this