TY - JOUR
T1 - Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart
AU - Abarbanell, Aaron M.
AU - Coffey, Arthur C.
AU - Fehrenbacher, John W.
AU - Beckman, Daniel J.
AU - Herrmann, Jeremy L.
AU - Weil, Brent
AU - Meldrum, Daniel R.
N1 - Funding Information:
This work was supported in part by the United States National Institutes of Health (NIH) R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077, NIH 1F32HL092718, NIH 1F32HL092719, American Heart Association Grant-in-Aid, and the American Heart Association Post-Doctoral Fellowship 0725663Z.
PY - 2009/9
Y1 - 2009/9
N2 - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.
AB - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.
UR - https://www.scopus.com/pages/publications/68849109142
U2 - 10.1016/j.athoracsur.2009.02.093
DO - 10.1016/j.athoracsur.2009.02.093
M3 - Review article
C2 - 19699961
AN - SCOPUS:68849109142
SN - 0003-4975
VL - 88
SP - 1036
EP - 1043
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -