@article{8dd3399aba1b4118910852769c502602,
title = "Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy",
abstract = "Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358–363.",
author = "{DIAN Investigators} and Zahra Shirzadi and Yau, {Wai Ying W.} and Schultz, {Stephanie A.} and Schultz, {Aaron P.} and Scott, {Matthew R.} and Maged Goubran and Parisa Mojiri-Forooshani and Nelly Joseph-Mathurin and Kejal Kantarci and Greg Preboske and Wermer, {Marieke J.H.} and Clifford Jack and Tammie Benzinger and Kevin Taddei and Sohrabi, {Hamid R.} and Sperling, {Reisa A.} and Johnson, {Keith A.} and Bateman, {Randall J.} and Martins, {Ralph N.} and Greenberg, {Steven M.} and Chhatwal, {Jasmeer P.}",
note = "Funding Information: This research was carried out in part at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies, , a P41 Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). This work also involved the use of instrumentation supported by the NIH Shared Instrumentation Grant Program and/or High‐End Instrumentation Grant Program; specifically, grant numbers S10RR021110, S10RR023401, and S10RR023043. P41EB015896 Funding Information: This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS070834) and the National Institute on Aging (Dominantly Inherited Alzheimer's Network; UF1AG032438; K23AG049087; P01AG036694). Zahra Shirzadi gratefully acknowledges a fellowship award from the Alzheimer's Society of Canada that supported this work. Last, data collection for this study was supported by the National Health and Medical Research Council grant (APP1129627) to Ralph N. Martins. Publisher Copyright: {\textcopyright} 2022 American Neurological Association.",
year = "2022",
month = sep,
doi = "10.1002/ana.26429",
language = "English",
volume = "92",
pages = "358--363",
journal = "Annals of Neurology",
issn = "0364-5134",
number = "3",
}