Progressive aphasia: A precursor of global dementia?

J. Green, J. C. Morris, J. Sandson, D. W. McKeel, J. W. Miller

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163 Scopus citations

Abstract

We studied 8 subjects longitudinally in whom isolated language dysfunction had developed gradually at a mean age of 62.8 years. The language deficits initially displayed by the subjects were characteristic of the syndrome of “progressive aphasia without dementia.” By 5 years after onset of progressive aphasia, however, 7 of the 8 subjects additionally had developed mild dementia as diagnosed by clinical means, and the remaining subject demonstrated declining performance in both verbal and nonverbal psychometric measures. Thus, generalized cognitive impairment occurred in all. Neuropathologic evidence of a diffuse dementing disorder was present in the 2 subjects studied postmortem. One had Alzheimer’s disease with disproportionate involvement of the left inferior parietal cortex, and the other displayed widespread neocortical neuronal loss and microvacuolation in the absence of specific histopathologic markers. In this series, progressive aphasia was a precursor of global dementia.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalNeurology
Volume40
Issue number3
DOIs
StatePublished - Mar 1990

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