TY - JOUR
T1 - Progression of chronic renal disease
AU - Klahr, Saulo
AU - Morrissey, Jeremiah
N1 - Funding Information:
We acknowledge the Commemorative Association for the Japan World Exposition (1970), Japanese Association of Dialysis Physicians, Osaka Pharmaceutical Manufacturers Association, and the Pharmaceutical Manufacturers Association of Tokyo for financial support to publish this supplement.
Funding Information:
S.K. ws supported by NIH grant no. PPG-P01-DK09976.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Risk factors for progression of kidney disease include hypertension, proteinuria, male sex, obesity, diabetes mellitus, hyperlipidemia, smoking, high-protein diets, phosphate retention, and metabolic acidosis. Angiotensin II production upregulates the expression of transforming growth factor-β1, tumor necrosis factor-α, nuclear factor-κB, and several adhesion molecules and chemoattractants. In addition to angiotensin, other vasoactive compounds, such as thromboxane A2, endothelin, and prostaglandins, are upregulated. Treatment with one of several growth factors may ameliorate the progression of kidney disease: insulin-like growth factor-1, hepatocyte growth factor, and bone morphogenetic protein-7.
AB - Risk factors for progression of kidney disease include hypertension, proteinuria, male sex, obesity, diabetes mellitus, hyperlipidemia, smoking, high-protein diets, phosphate retention, and metabolic acidosis. Angiotensin II production upregulates the expression of transforming growth factor-β1, tumor necrosis factor-α, nuclear factor-κB, and several adhesion molecules and chemoattractants. In addition to angiotensin, other vasoactive compounds, such as thromboxane A2, endothelin, and prostaglandins, are upregulated. Treatment with one of several growth factors may ameliorate the progression of kidney disease: insulin-like growth factor-1, hepatocyte growth factor, and bone morphogenetic protein-7.
KW - Angiotensin II
KW - Nuclear factor-κB (NF-κB)
KW - Transforming growth factor-β1 (TGF-β1)
KW - Tumor necrosis factor-α (TNF-α)
UR - http://www.scopus.com/inward/record.url?scp=0037374219&partnerID=8YFLogxK
U2 - 10.1053/ajkd.2003.50074
DO - 10.1053/ajkd.2003.50074
M3 - Article
C2 - 12612942
AN - SCOPUS:0037374219
SN - 0272-6386
VL - 41
SP - S3-S7
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 3 SUPPL. 1
ER -