Progress in vaccine development for infectious diseases—a Keystone Symposia report

Jennifer Cable; Barney S. Graham; Richard A. Koup; Robert A. Seder; Katalin Karikó; Norbert Pardi; Dan H. Barouch; Bhawna Sharma; Susanne Rauch; Raffael Nachbagauer; Mattias N.E. Forsell; Michael Schotsaert; Ali H. Ellebedy; Karin Loré; Darrell J. Irvine; Emily Pilkington; Siri Tahtinen; Elizabeth A. Thompson; Yanis Feraoun; Neil P. King; Kevin Saunders; Galit Alter; Syed M. Moin; Kwinten Sliepen; Gunilla B. Karlsson Hedestam; Hedda Wardemann; Bali Pulendran; Nicole A. Doria-Rose; Wan Ting He; Jennifer A. Juno; Sila Ataca; Adam K. Wheatley; Jason S. McLellan; Laura M. Walker; Julia Lederhofer; Lisa C. Lindesmith; Holger Wille; Peter J. Hotez; Linda Gail Bekker

doi:10.1111/nyas.14975

Progress in vaccine development for infectious diseases—a Keystone Symposia report

Jennifer Cable, Barney S. Graham, Richard A. Koup, Robert A. Seder, Katalin Karikó, Norbert Pardi, Dan H. Barouch, Bhawna Sharma, Susanne Rauch, Raffael Nachbagauer, Mattias N.E. Forsell, Michael Schotsaert, Ali H. Ellebedy, Karin Loré, Darrell J. Irvine, Emily Pilkington, Siri Tahtinen, Elizabeth A. Thompson, Yanis Feraoun, Neil P. KingKevin Saunders, Galit Alter, Syed M. Moin, Kwinten Sliepen, Gunilla B. Karlsson Hedestam, Hedda Wardemann, Bali Pulendran, Nicole A. Doria-Rose, Wan Ting He, Jennifer A. Juno, Sila Ataca, Adam K. Wheatley, Jason S. McLellan, Laura M. Walker, Julia Lederhofer, Lisa C. Lindesmith, Holger Wille, Peter J. Hotez, Linda Gail Bekker

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Abstract

The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies’ preparedness for future pandemics. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.

Original language	English
Pages (from-to)	65-86
Number of pages	22
Journal	Annals of the New York Academy of Sciences
Volume	1524
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14975
State	Published - Jun 2023

Keywords

antigen design
mRNA vaccines
structural vaccinology
vaccine delivery
vaccine hesitancy
vaccines

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10.1111/nyas.14975

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Cable, J., Graham, B. S., Koup, R. A., Seder, R. A., Karikó, K., Pardi, N., Barouch, D. H., Sharma, B., Rauch, S., Nachbagauer, R., Forsell, M. N. E., Schotsaert, M., Ellebedy, A. H., Loré, K., Irvine, D. J., Pilkington, E., Tahtinen, S., Thompson, E. A., Feraoun, Y., ... Bekker, L. G. (2023). Progress in vaccine development for infectious diseases—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1524(1), 65-86. https://doi.org/10.1111/nyas.14975

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title = "Progress in vaccine development for infectious diseases—a Keystone Symposia report",

abstract = "The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies{\textquoteright} preparedness for future pandemics. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.",

keywords = "antigen design, mRNA vaccines, structural vaccinology, vaccine delivery, vaccine hesitancy, vaccines",

author = "Jennifer Cable and Graham, {Barney S.} and Koup, {Richard A.} and Seder, {Robert A.} and Katalin Karik{\'o} and Norbert Pardi and Barouch, {Dan H.} and Bhawna Sharma and Susanne Rauch and Raffael Nachbagauer and Forsell, {Mattias N.E.} and Michael Schotsaert and Ellebedy, {Ali H.} and Karin Lor{\'e} and Irvine, {Darrell J.} and Emily Pilkington and Siri Tahtinen and Thompson, {Elizabeth A.} and Yanis Feraoun and King, {Neil P.} and Kevin Saunders and Galit Alter and Moin, {Syed M.} and Kwinten Sliepen and {Karlsson Hedestam}, {Gunilla B.} and Hedda Wardemann and Bali Pulendran and Doria-Rose, {Nicole A.} and He, {Wan Ting} and Juno, {Jennifer A.} and Sila Ataca and Wheatley, {Adam K.} and McLellan, {Jason S.} and Walker, {Laura M.} and Julia Lederhofer and Lindesmith, {Lisa C.} and Holger Wille and Hotez, {Peter J.} and Bekker, {Linda Gail}",

note = "Publisher Copyright: {\textcopyright} 2023 New York Academy of Sciences.",

year = "2023",

month = jun,

doi = "10.1111/nyas.14975",

language = "English",

volume = "1524",

pages = "65--86",

journal = "Annals of the New York Academy of Sciences",

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Cable, J, Graham, BS, Koup, RA, Seder, RA, Karikó, K, Pardi, N, Barouch, DH, Sharma, B, Rauch, S, Nachbagauer, R, Forsell, MNE, Schotsaert, M, Ellebedy, AH, Loré, K, Irvine, DJ, Pilkington, E, Tahtinen, S, Thompson, EA, Feraoun, Y, King, NP, Saunders, K, Alter, G, Moin, SM, Sliepen, K, Karlsson Hedestam, GB, Wardemann, H, Pulendran, B, Doria-Rose, NA, He, WT, Juno, JA, Ataca, S, Wheatley, AK, McLellan, JS, Walker, LM, Lederhofer, J, Lindesmith, LC, Wille, H, Hotez, PJ & Bekker, LG 2023, 'Progress in vaccine development for infectious diseases—a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1524, no. 1, pp. 65-86. https://doi.org/10.1111/nyas.14975

TY - JOUR

T1 - Progress in vaccine development for infectious diseases—a Keystone Symposia report

AU - Cable, Jennifer

AU - Graham, Barney S.

AU - Koup, Richard A.

AU - Seder, Robert A.

AU - Karikó, Katalin

AU - Pardi, Norbert

AU - Barouch, Dan H.

AU - Sharma, Bhawna

AU - Rauch, Susanne

AU - Nachbagauer, Raffael

AU - Forsell, Mattias N.E.

AU - Schotsaert, Michael

AU - Ellebedy, Ali H.

AU - Loré, Karin

AU - Irvine, Darrell J.

AU - Pilkington, Emily

AU - Tahtinen, Siri

AU - Thompson, Elizabeth A.

AU - Feraoun, Yanis

AU - King, Neil P.

AU - Saunders, Kevin

AU - Alter, Galit

AU - Moin, Syed M.

AU - Sliepen, Kwinten

AU - Karlsson Hedestam, Gunilla B.

AU - Wardemann, Hedda

AU - Pulendran, Bali

AU - Doria-Rose, Nicole A.

AU - He, Wan Ting

AU - Juno, Jennifer A.

AU - Ataca, Sila

AU - Wheatley, Adam K.

AU - McLellan, Jason S.

AU - Walker, Laura M.

AU - Lederhofer, Julia

AU - Lindesmith, Lisa C.

AU - Wille, Holger

AU - Hotez, Peter J.

AU - Bekker, Linda Gail

PY - 2023/6

Y1 - 2023/6

N2 - The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies’ preparedness for future pandemics. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.

AB - The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies’ preparedness for future pandemics. On June 1–4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium “Progress in Vaccine Development for Infectious Diseases” to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.

KW - antigen design

KW - mRNA vaccines

KW - structural vaccinology

KW - vaccine delivery

KW - vaccine hesitancy

KW - vaccines

UR - http://www.scopus.com/inward/record.url?scp=85163921821&partnerID=8YFLogxK

U2 - 10.1111/nyas.14975

DO - 10.1111/nyas.14975

M3 - Article

C2 - 37020354

AN - SCOPUS:85163921821

SN - 0077-8923

VL - 1524

SP - 65

EP - 86

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

IS - 1

ER -

Progress in vaccine development for infectious diseases—a Keystone Symposia report

Abstract

Keywords

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