TY - JOUR
T1 - Progress in translational research on intracerebral hemorrhage
T2 - Is there an end in sight?
AU - Xi, Guohua
AU - Strahle, Jennifer
AU - Hua, Ya
AU - Keep, Richard F.
N1 - Publisher Copyright:
© 2013 Elsevier Ltd.
PY - 2014
Y1 - 2014
N2 - Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which specific therapies and treatments remain elusive. To address this, many recent experimental and translational studies of ICH have been conducted, and these have led to several ongoing clinical trials. This review focuses on the progress of translational studies of ICH including those of the underlying causes and natural history of ICH, animal models of the condition, and effects of ICH on the immune and cardiac systems, among others. Current and potential clinical trials also are discussed for both ICH alone and with intraventricular extension.
AB - Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which specific therapies and treatments remain elusive. To address this, many recent experimental and translational studies of ICH have been conducted, and these have led to several ongoing clinical trials. This review focuses on the progress of translational studies of ICH including those of the underlying causes and natural history of ICH, animal models of the condition, and effects of ICH on the immune and cardiac systems, among others. Current and potential clinical trials also are discussed for both ICH alone and with intraventricular extension.
KW - Animal models
KW - Brain edema
KW - Intracerebral hemorrhage
KW - Iron
UR - http://www.scopus.com/inward/record.url?scp=84886731334&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2013.09.007
DO - 10.1016/j.pneurobio.2013.09.007
M3 - Review article
C2 - 24139872
AN - SCOPUS:84886731334
SN - 0301-0082
VL - 115
SP - 45
EP - 63
JO - Progress in Neurobiology
JF - Progress in Neurobiology
IS - C
ER -