TY - JOUR
T1 - Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred
AU - Barr, C. L.
AU - Kennedy, J. L.
AU - Pakstis, A. J.
AU - Wetterberg, L.
AU - Sjogren, B.
AU - Bierut, L.
AU - Wadelius, C.
AU - Wahlstrom, J.
AU - Martinsson, T.
AU - Giuffra, L.
AU - Gelernter, J.
AU - Hallmayer, J.
AU - Moises, H. W.
AU - Kurth, J.
AU - Cavalli-Sforza, L. L.
AU - Kidd, K. K.
PY - 1994
Y1 - 1994
N2 - Genetic linkage studies of a kindred from Sweden segregating for schizophrenia have been performed using a genetic model (autosomal dominant, f = 0.72, q = 0.02, phenocopies = 0.001) as described in Kennedy et al., 1988. Analyses of the restriction fragment length polymorphism (RFLP), allele-specific oligonucleotides (ASO), and short tandem repeat (STR also called microsatellite) data for 180 polymorphisms (individual probe-enzyme, ASO, or STR systems) at 155 loci have been completed using the MLINK and LIPED programs. Linkage to schizophrenia was excluded, under the given model, at 47 loci; indeterminate lod scores occurred at 108 loci. The total exclusion region across 20 chromosomes is estimated at 330 cM; 211 cM excluded by pairwise analyses and 119 cM previously excluded by multipoint analyses (Kennedy et al., 1989: Schizophr Bull 15:383-391; Moises et al. 1991: Genet Epidemiol 2:99-110; Hallmayer et al., 1992: Arch Gen Psychiatry 49:216-219).
AB - Genetic linkage studies of a kindred from Sweden segregating for schizophrenia have been performed using a genetic model (autosomal dominant, f = 0.72, q = 0.02, phenocopies = 0.001) as described in Kennedy et al., 1988. Analyses of the restriction fragment length polymorphism (RFLP), allele-specific oligonucleotides (ASO), and short tandem repeat (STR also called microsatellite) data for 180 polymorphisms (individual probe-enzyme, ASO, or STR systems) at 155 loci have been completed using the MLINK and LIPED programs. Linkage to schizophrenia was excluded, under the given model, at 47 loci; indeterminate lod scores occurred at 108 loci. The total exclusion region across 20 chromosomes is estimated at 330 cM; 211 cM excluded by pairwise analyses and 119 cM previously excluded by multipoint analyses (Kennedy et al., 1989: Schizophr Bull 15:383-391; Moises et al. 1991: Genet Epidemiol 2:99-110; Hallmayer et al., 1992: Arch Gen Psychiatry 49:216-219).
KW - genetics
KW - linkage
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0028107678&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320540110
DO - 10.1002/ajmg.1320540110
M3 - Article
C2 - 7909991
AN - SCOPUS:0028107678
SN - 0148-7299
VL - 54
SP - 51
EP - 58
JO - American journal of medical genetics
JF - American journal of medical genetics
IS - 1
ER -