@article{5ebabcc65a6247e5a3685f60d7129f59,
title = "Progress and perspectives in plant sterol and plant stanol research",
abstract = "Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.",
keywords = "Cholesterol, Nutrition, Plant stanols, Plant sterols, Sitosterolemia",
author = "Jones, {Peter J.H.} and Maryam Shamloo and MacKay, {Dylan S.} and Rideout, {Todd C.} and Myrie, {Semone B.} and Jogchum Plat and Roullet, {Jean Baptiste} and Baer, {David J.} and Calkins, {Kara L.} and Davis, {Harry R.} and Duell, {P. Barton} and Henry Ginsberg and Helena Gylling and David Jenkins and Dieter L{\"u}tjohann and Mohammad Moghadasian and Moreau, {Robert A.} and David Mymin and Ostlund, {Richard E.} and Ras, {Rouyanne T.} and Reparaz, {Javier Ochoa} and Trautwein, {Elke A.} and Stephen Turley and Tim Vanmierlo and Oliver Weing{\"a}rtner",
note = "Funding Information: The authors would like to express their gratitude to the International Plant Sterol and Stanol Association (IPSSA) as key sponsor of the conference. The conference was also supported by a grant from the National Center for Complementary and Integrative Health (NCCIH) and the National Center for Advancing Translational Sciences to J.-B. Roullet (IR13AT009270-01). The authors also thank Louise Grapentine and Jennifer Palichuk at the Richardson Centre for Functional Foods and Nutraceuticals for outstanding administrative support. Finally, the authors thank all speakers and participants for their engagement in the discussion during this meeting. Funding Information: Funding/support. The authors would like to express their gratitude to the International Plant Sterol and Stanol Association (IPSSA) as key sponsor of the conference. The conference was also supported by a grant from the National Center for Complementary and Integrative Health (NCCIH) and the National Center for Advancing Translational Sciences to J.-B. Roullet (IR13AT009270–01). The authors also thank Louise Grapentine and Jennifer Palichuk at the Richardson Centre for Functional Foods and Nutraceuticals for outstanding administrative support. Finally, the authors thank all speakers and participants for their engagement in the discussion during this meeting. Funding Information: Declaration of interest. M.S., D.S.M., S.B.M., J.P., D.J.B., H.R.D., P.B.D., R.A.M., J-B.R., H.Gin, H. Gyl, D.J., D.L., M.M., D.M., J.O.R. T.V., and S.T. have no relevant interests to declare. R.T.R. and E.A.T. are employed by Unilever R&D. Unilever markets food products with added plant sterols. R.E.O.Jr has participated in the program BASF Nutrition & Health—Asia. O.W. has received speaker honoraria from Amgen, Berlin-Chemie Menarini, Merck & Co, and Sanofi and serves on advisory boards for Amgen, Merck & Co, and Berlin-Chemie Menarini. K.L.C. has received funding from the National Institutes of Health/National Center for Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = oct,
day = "1",
doi = "10.1093/nutrit/nuy032",
language = "English",
volume = "76",
pages = "725--746",
journal = "Nutrition Reviews",
issn = "0029-6643",
number = "10",
}