Prognostic significance of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH-1) mutation in glioblastoma multiforme patients: A single-center experience in the Middle East region

Zeina Ayoub, Fady Geara, Marwan Najjar, Youssef Comair, Nathalie Khoueiry-Zgheib, Pierre Khoueiry, Rami Mahfouz, Fouad I. Boulos, Francois G. Kamar, Therese Andraos, Fadi Saadeh, Firas Kreidieh, Miguel Abboud, Ghassan Skaf, Hazem I. Assi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: To determine the prevalence and prognostic value of MGMT promoter methylation and IDH1 mutation in glioblastoma multiforme (GBM) patients from the Middle East. Patients and methods: Records of patients diagnosed between 2003 and 2015 were reviewed. MGMT promoter methylation was measured using methylation-specific polymerase chain reaction and IDH-1 mutation was reported. The primary endpoint was overall survival (OS). Results: A total of 110 patients were included. The median age was 51 years and 71 patients (64.5%) were males. The median diameter of GBM was 4.6 cm and 29 patients (26.4%) had multifocal disease. Gross total resection was achieved in 38 patients (24.9%). All patients received adjuvant radiation therapy, and 96 patients (91.4%) received concomitant temozolomide. At a median follow up of 13.6 months, the median OS was 17.2 months, and the OS at 1 and 2 years were 71.6% and 34.8%, respectively. On multivariate analysis, age at diagnosis (HR 1.019; P = 0.044) and multifocality (HR 2.373; P = 0.001) were the only independent prognostic variables. MGMT promoter methylation was found in 28.2% of patients but did not significantly correlate with survival (HR 1.160; P = 0.635). IDH-1 mutation was found in 10% of patients was associated with a non-significant trend for survival improvement (HR 0.502; P = 0.151). Conclusion: Patients with GBM from the Middle East have adequate survival outcomes when given the optimal treatment. In our patient population, MGMT promoter methylation did not seem to correlate with outcomes, but patients with IDH1 mutation had numerically higher survival outcomes.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalClinical Neurology and Neurosurgery
Volume182
DOIs
StatePublished - Jul 2019

Keywords

  • Glioblastoma multiforme
  • IDH-1 mutation
  • MGMT promoter methylation
  • Middle East region

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