Prognostic significance of multidetector computed tomography in normotensive patients with pulmonary embolism: Rationale, methodology and reproducibility for the PROTECT study

David Jiménez, José Luis Lobo, Manuel Monreal, Remedios Otero, Roger D. Yusen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The PROTECT study is designed to assess the prognostic significance of multidetector computed tomography (MDCT) findings in normotensive outpatients with pulmonary embolism (PE). MDCT assesses right ventricular dysfunction (RVD) by measuring the ratio of the rightto- left ventricular short axis diameters. The study uses 30-day all-cause mortality as the primary outcome. The study determined inter- and intraobserver reproducibility of CT findings of RVD. According to the local radiologists' measurements, 44 % of patients (42/96) showed RVD (defined as a ratio of the RV to the LV short axis greater than 0.9). The intraclass correlation was good (0.773, CI 95 %, 0.678-0.842). For interobserver reproducibility, the weighted kappa measurement was 0.730. Intraobserver reproducibility was very good (0.932, 95 % CI, 0.880- 0.962). The PROTECT study is designed to show the prognostic significance of MDCT for PE. Inter- and intraobserver agreement of interpretation of RVD were good.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalJournal of Thrombosis and Thrombolysis
Volume34
Issue number2
DOIs
StatePublished - Aug 2012

Keywords

  • Computed tomography
  • Prognosis
  • Pulmonary embolism

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