TY - JOUR
T1 - Prognostic significance and extra-hypothalamus dysfunction of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 encephalitis
AU - Liu, Xiao
AU - Li, Gongfei
AU - Yu, Tingting
AU - Lv, Ruijuan
AU - Cui, Tao
AU - Hogan, R. Edward
AU - Wang, Qun
N1 - Funding Information:
The study was financially supported by the National Key Research and Development Program of China grant ( 2017YFC1307500 ); the Capital Health Research and Development of Special grants ( 2020−1−2013 ); the Beijing-Tianjin-Hebei Cooperative Basic Research Program ( H2018206435 ); the Beijing Natural Science Foundation ( Z200024 ).
Publisher Copyright:
© 2022
PY - 2022/12/15
Y1 - 2022/12/15
N2 - This study aimed to investigate prognostic significance and brain metabolic mechanism of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis. After adjusting for confounders, patients with moderate and severe hyponatremia had significantly increased risk of poor functional outcome and sequelae of seizures. In addition, serum sodium was negatively correlated with normalized ratio of the standardized uptake value of medial temporal lobe (MTL), basal ganglia (BG), and hypothalamus on positron emission tomography (PET) and which was further validated using voxel-wise analysis, suggesting an extra-hypothalamus (BG and MTL) localization for hyponatremia.
AB - This study aimed to investigate prognostic significance and brain metabolic mechanism of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis. After adjusting for confounders, patients with moderate and severe hyponatremia had significantly increased risk of poor functional outcome and sequelae of seizures. In addition, serum sodium was negatively correlated with normalized ratio of the standardized uptake value of medial temporal lobe (MTL), basal ganglia (BG), and hypothalamus on positron emission tomography (PET) and which was further validated using voxel-wise analysis, suggesting an extra-hypothalamus (BG and MTL) localization for hyponatremia.
KW - Autoimmune encephalitis
KW - Hyponatremia
KW - Leucine-rich glioma-inactivated protein 1
KW - Positron emission tomography
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85142172788&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2022.578000
DO - 10.1016/j.jneuroim.2022.578000
M3 - Article
C2 - 36410057
AN - SCOPUS:85142172788
SN - 0165-5728
VL - 373
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 578000
ER -