Prognostic Markers of Outcome in Patients Undergoing Infra-inguinal Revascularisation: A Prospective Observational Pilot Study

M. Kanakaraj, D. R. Yates, R. J.T. Wilson, M. L. Baroni, S. J. Davies

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives The aim was to investigate whether cardiopulmonary exercise testing (CPET) variables derived from cycle and arm ergonometry correlate, and whether CPET variables and pre-operative N-terminal pro-brain natriuretic peptide (NT-proBNP) have prognostic significance and if the combination of the two has incremental value. Methods A prospective observational pilot study was conducted; 70 patients who underwent infra-inguinal bypass surgery were recruited. Pre-operatively subjects underwent CPET with both arm and leg ergonometry, to measure peak oxygen consumption, anaerobic threshold (AT), and ventilatory equivalents. In addition pre-operative serum samples of NT-proBNP were obtained. The primary endpoint was 1 year all-cause mortality; in addition, data were collected on complications, morbidity, length of stay, and major adverse cardiac events (MACE). Results The 1 year mortality rate was 6%, the overall complications rate was 23%, and the combined incidence of MACE and 1 year mortality was 10%. Cycle ergonometry peak VO2 14 mL/kg/min (RR 5.5, 95% CI 1.4–22.4, p =.007) and AT < 10mL/kg/min (RR 3.0, 95% CI 1.1–7.0, p =.03) were predictors of post-operative complications. Pre-operative NT-proBNP > 320 ng/L (RR 18, 95% CI 2.5–140 p =.0003) was the sole predictor of 1 year mortality or MACE. Conclusion The measurement of pre-operative NT-proBNP in peripheral vascular disease patients undergoing infra-inguinal bypass can predict 1 year mortality and MACE. CPET variables from cycle ergonometry are predictors of post-operative complications in this patient group.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number2
StatePublished - Aug 2017


  • Anaerobic threshold
  • Arm crank
  • Bike test
  • Cardiopulmonary Exercise test
  • Lower limb revascularisation
  • NT-proBNP
  • Peak VO
  • Peripheral vascular disease


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