Prognostic Differences: Epstein-Barr Virus–Associated Primary Leiomyosarcoma of the Spine Versus Spinal Leiomyosarcoma Metastases

Nitin Agarwal, David R. Hansberry, Ami Kavi, Prateek Agarwal, Ada Baisre, Ira M. Goldstein

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Objective The authors studied 6 cases of osseous leiomyosarcoma of the spine. Two of these cases were of immunocompromised human immunodeficiency virus (HIV)-positive patients with Epstein-Barr virus (EBV)-associated primary vertebral leiomyosarcomas. The remaining 4 cases were of patients with leiomyosarcoma metastases to the spine. Methods Each patient underwent surgical resection of their vertebral mass; however, the patients with the EBV-associated tumors had the best postoperative prognosis. Results The HIV-positive patients have had no further local recurrence, while the other 4 patients had rapid local recurrences requiring multiple surgical interventions. Furthermore, the patients living with HIV have lived longer with fewer leiomyosarcoma-related health complications. Conclusions These findings suggest that EBV-associated vertebral leiomyosarcoma is of a less aggressive variety than metastatic leiomyosarcoma of the spine.

Original languageEnglish
Pages (from-to)484-490
Number of pages7
JournalWorld neurosurgery
Volume99
DOIs
StatePublished - Mar 1 2017

Keywords

  • AIDS
  • Metastatic leiomyosarcoma
  • Spinal leiomyosarcoma
  • Spinal metastasis

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