Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature

Keyphrases

• Aging 100%
• Vascular Smooth muscle Cells 100%
• Replication Stress 100%
• Phenotypic Switching 100%
• Progerin 100%
• Cell Loss 20%
• Genomic Instability 20%
• Profibrotic 20%
• Muscle Cell Death 20%
• Telomere Fragility 20%
• RNA-seq Analysis 10%
• Extracellular Matrix 10%
• Vascular Stiffness 10%
• Large Artery Atherosclerosis 10%
• Age-related Illnesses 10%
• Vasculature 10%
• Premature Aging 10%
• Calcitriol 10%
• Phenotypic Plasticity 10%
• Secretory Phenotype 10%
• Cell Depletion 10%
• Inflammatory Signature 10%
• Synthetic Phenotype 10%
• Progeria 10%
• Hutchinson-Gilford Progeria Syndrome 10%
• Adventitial Layer 10%
• Medial Layer 10%
• Prelamin A 10%
• LMNA Gene mutation 10%

Biochemistry, Genetics and Molecular Biology

• Progerin 100%
• Cell Loss 28%
• Cell Death 28%
• Genome Instability 28%
• Progeria 28%
• Telomere 28%
• Gene Mutation 14%
• Vascularization 14%
• RNA Sequencing 14%
• LMNA 14%
• Phenotypic Plasticity 14%
• Arterial Stiffness 14%
• Calcitriol 14%