@article{bef0ade94850467995bdb29fb9360f31,
title = "Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans",
abstract = "Peripheral sensory neurons located in dorsal root ganglia relay sensory information from the peripheral tissue to the brain. Satellite glial cells (SGCs) are unique glial cells that form an envelope completely surrounding each sensory neuron soma. This organization allows for close bidirectional communication between the neuron and its surrounding glial coat. Morphological and molecular changes in SGC have been observed in multiple pathological conditions such as inflammation, chemotherapy-induced neuropathy, viral infection, and nerve injuries. There is evidence that changes in SGC contribute to chronic pain by augmenting the neuronal activity in various rodent pain models. Satellite glial cells also play a critical role in axon regeneration. Whether findings made in rodent model systems are relevant to human physiology have not been investigated. Here, we present a detailed characterization of the transcriptional profile of SGC in mice, rats, and humans at the single cell level. Our findings suggest that key features of SGC in rodent models are conserved in humans. Our study provides the potential to leverage rodent SGC properties and identify potential targets in humans for the treatment of nerve injuries and alleviation of painful conditions.",
keywords = "DRG, Human, Mouse, Pain, Rat, Regeneration, Satellite glial cells, Single-cell RNA-seq",
author = "Oshri Avraham and Alexander Chamessian and Rui Feng and Lite Yang and Halevi, {Alexandra E.} and Amy Moore and Gereau, {Robert W.} and Valeria Cavalli",
note = "Funding Information: This research was funded in part by a postdoctoral fellowship from The McDonnell Center for Cellular and Molecular Neurobiology to O. Avraham, by NIH grant NS042595 to R. W. Gereau, by The McDonnell Center for Cellular and Molecular Neurobiology to V. Cavalli, by a Pilot Project Award from the Hope Center for Neurological Disorders at Washington University to V. Cavalli and by NIH grants NS111719, NS122260, and NS115492 to V. Cavalli. The authors thank Greg Strout, Ross Kossina, and Dr James Fitzpatrick from the Washington University Center for Cellular Imaging, which is supported in part by the Washington University School of Medicine, The Children's Discovery Institute of Washington University, and St. Louis Children's Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770) for assistance in acquiring and interpreting transmission electron microscopy data. The authors thank the human tissue donor families for their generous donations to science, which made the human tissue work presented here possible. The authors thank Mid-America Transplant for providing access to donor tissue and their facilities and J. Lemen for his time and surgical skill in assisting with hDRG extractions. Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",
year = "2022",
month = dec,
day = "1",
doi = "10.1097/j.pain.0000000000002628",
language = "English",
volume = "163",
pages = "2348--2364",
journal = "Pain",
issn = "0304-3959",
number = "12",
}