TY - JOUR
T1 - Profiling of miRNA expression in immune thrombocytopenia patients before and after Qishunbaolier (QSBLE) treatment
AU - Burenbatu,
AU - Borjigin, Mandula
AU - Eerdunduleng,
AU - Huo, Wenyan
AU - Gong, Cuiqin
AU - Hasengaowa,
AU - Zhang, Guiping
AU - Longmei,
AU - Li, Ming
AU - Zhang, Xuemei
AU - Sun, Xiaohui
AU - Yang, Jie
AU - Wang, Shuanglian
AU - Narisu, Narisu
AU - Liu, Yangjian
AU - Bai, Haihua
N1 - Publisher Copyright:
© 2015 Elsevier Masson SAS.
PY - 2015/10
Y1 - 2015/10
N2 - Immune thrombocytopenia (ITP), also known as idiopathic thrombocytopenic purpura, is an autoimmune disease characterized by low platelet count and increased bleeding tendency. Currently, glucocorticoid and splenectomy are the main therapies for ITP but with obvious side effects including tendency of relapse and risk of internal bleeding. In this study, we report the Mongolian medicine Qishunbaolier (QSBLE) can significantly and efficiently increase platelet count with a low recurrent rate and unnoticeable side effect. We profiled the microRNA (miRNA) expression in the blood sample of ITP patients and identified 44 miRNAs that are differentially expressed in ITP patients before and after QSBLE treatment. Out of these 44 miRNAs, 25 are expressed in control subjects and are downregulated in ITP patients, whereas the treatment with QSBLE restores their expressions to the level of control subjects. This result suggests that abnormal expression of these 25 miRNAs might be connected to the pathogenesis of ITP. Interestingly, 14 of those 44 miNRAs are predicted to target at least once on 31 known IPT associated genes, indicating the possible mechanism of QSBLE on ITP therapy.
AB - Immune thrombocytopenia (ITP), also known as idiopathic thrombocytopenic purpura, is an autoimmune disease characterized by low platelet count and increased bleeding tendency. Currently, glucocorticoid and splenectomy are the main therapies for ITP but with obvious side effects including tendency of relapse and risk of internal bleeding. In this study, we report the Mongolian medicine Qishunbaolier (QSBLE) can significantly and efficiently increase platelet count with a low recurrent rate and unnoticeable side effect. We profiled the microRNA (miRNA) expression in the blood sample of ITP patients and identified 44 miRNAs that are differentially expressed in ITP patients before and after QSBLE treatment. Out of these 44 miRNAs, 25 are expressed in control subjects and are downregulated in ITP patients, whereas the treatment with QSBLE restores their expressions to the level of control subjects. This result suggests that abnormal expression of these 25 miRNAs might be connected to the pathogenesis of ITP. Interestingly, 14 of those 44 miNRAs are predicted to target at least once on 31 known IPT associated genes, indicating the possible mechanism of QSBLE on ITP therapy.
KW - Immune thrombocytopenia
KW - MicroRNA expression
KW - Mongolian medicine
KW - Qishunbaolier treatment
UR - http://www.scopus.com/inward/record.url?scp=84944178133&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2015.07.022
DO - 10.1016/j.biopha.2015.07.022
M3 - Article
C2 - 26297543
AN - SCOPUS:84944178133
SN - 0753-3322
VL - 75
SP - 196
EP - 204
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -