Profile of acute tolerance to three sedative anxiolytics

Everett H. Ellinwood; Markku Linnoila; Martha E. Easler; David W. Molter

doi:10.1007/BF00427800

Profile of acute tolerance to three sedative anxiolytics

Everett H. Ellinwood, Markku Linnoila, Martha E. Easler, David W. Molter

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Abstract

Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.

Original language	English
Pages (from-to)	137-141
Number of pages	5
Journal	Psychopharmacology
Volume	79
Issue number	2-3
DOIs	https://doi.org/10.1007/BF00427800
State	Published - Feb 1983

Keywords

Acute tolerance
Peak impairment
Plasma concentration
Sedative anxiolytics

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10.1007/BF00427800

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Profile of acute tolerance to three sedative anxiolytics

Abstract

Keywords

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