Productive replication of human adenovirus type 5 in canine cells

Vladimir V. Ternovoi, Long P. Le, Natalya Belousova, Bruce F. Smith, Gene P. Siegal, David T. Curiel

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Development of immunocompetent patient-like models that allow direct analysis of human adenovirus-based conditionally replicative adenoviruses (CRAds) would be beneficial for the advancement of these oncolytic agents. To this end, we explored the possibility of cross-species replication of human adenovirus type 5 (Ad5) in canine cells. With a panel of canine tumor cell lines of both epithelial and mesenchymal derivations, we demonstrate that human Ad5 can productively infect canine cells. Since the biological behavior and clinical presentation of certain dog tumors closely resemble those of their human counterparts, our results raise the possibility of exploiting canine models for preclinical analysis of candidate CRAd agents designed for human virotherapy.

Original languageEnglish
Pages (from-to)1308-1311
Number of pages4
JournalJournal of virology
Volume79
Issue number2
DOIs
StatePublished - Jan 2005

Fingerprint

Dive into the research topics of 'Productive replication of human adenovirus type 5 in canine cells'. Together they form a unique fingerprint.

Cite this