Production, processing and small animal PET imaging of titanium-45

Amy L. Vavere, Richard Laforest, Michael J. Welch

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Titanium-45 was prepared as a tool for elucidation of the mechanism of action of titanium anticancer drugs in vivo using microPET imaging. Titanium-45 was produced by the 45Sc(p,n)45Ti nuclear reaction using 14.5 MeV protons. Sufficient yields of 45Ti were produced and separated from the target material with 99.8% radionuclidic purity using a simple, efficient separation procedure. A typical bombardment of 5 μA for 1 h produced an average of 2105±150 MBq (56.9±4.0 mCi) at the end of bombardment (EOB), well within acceptable range of the calculated theoretical yields of 2165 MBq and 433 MBq μA-1 h-1 (58.5 mCi and 11.7 mCi μA-1 h-1). This amount of activity is sufficient for the radiosynthesis of target compounds as well as imaging studies. MicroPET images of a miniature Derenzo phantom show excellent resolution where rods of 1.25 mm were separated by four times their diameter. Titanium-45 can be easily produced on a biomedical cyclotron with excellent yields as compared to calculated theoretical values with imaging studies demonstrating that the decay properties of titanium-45 are well suited for microPET.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalNuclear Medicine and Biology
Volume32
Issue number2
DOIs
StatePublished - Feb 2005

Keywords

  • Ion chromatography
  • MicroPET
  • Titanium-45

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