Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

Brian J. Laidlaw, Weiguo Cui, Robert A. Amezquita, Simon M. Gray, Tianxia Guan, Yisi Lu, Yasushi Kobayashi, Richard A. Flavell, Steven H. Kleinstein, Joe Craft, Susan M. Kaech

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Memory CD8+ T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells (Treg cells) was necessary for the maturation of memory CD8+ T cells following acute infection with lymphocytic choriomeningitis virus (LCMV). Treg cell-derived IL-10 was most important during the resolution phase, calming inflammation and the activation state of dendritic cells. Adoptive transfer of IL-10-sufficient Treg cells during the resolution phase 'restored' the maturation of memory CD8+ T cells in IL-10-deficient mice. Our data indicate that Treg cell-derived IL-10 is needed to insulate CD8+ T cells from inflammatory signals, and reveal that the resolution phase of infection is a critical period that influences the quality and function of developing memory CD8+ T cells.

Original languageEnglish
Pages (from-to)871-879
Number of pages9
JournalNature immunology
Volume16
Issue number8
DOIs
StatePublished - Jul 21 2015

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