TY - JOUR
T1 - Production of an Antigen-Specific Component of Suppressor Inducer Factor by a Helper T-Cell Clone
T2 - Possible Role for IL-1 at the Interface of Immunity and Tolerance
AU - Green, D. R.
AU - Chue, B.
AU - Ferguson, T. A.
AU - Beaman, K. D.
AU - Flood, P. M.
PY - 1985/1
Y1 - 1985/1
N2 - When immunological homocostasis is disrupted by the introduction of substances which cannot be accommodated as self, a dynamic cellular interaction of the immune system ensues which may result in a positive state (immune response with subsequent memory) or in a negative one (immune unrcsponsiveness with subsequent tolerance) While much is known about both positive and negative states of immune function, relatively little work has focused upon the precise mechanisms of the decision-making process We have examined the potential roles of IL-1 in this process. Using a well defined helper T-cell clone (D10.G4 1) and antigen-pulsed splenic adherent cells we have found that a number of agents which block the induction or action of IL-1 (ultraviolet irradiation of APC. addition of cyclosponn A, addition of anti-L3T4 antibody) resulted in the production, by the clone, of an antigen-specific factor involved in the induction of a suppressor T-cell circuit This factor showed the same antigenic specificity as the helper cell (which is normally specific for antigen plus self la), and resembled by form and function a number of well characterized antigen-specific suppressor inducer molecules Crude preparations containing IL-1 prevented the appearance of this suppressor inducer factor These observations underline the pivotal role of the APC-hclpcr T-cell interaction in determining, in part, whether immunity or suppression will follow exposure to an antigen and thus, the immunorcgulatory outcome of an antigcnic challenge.
AB - When immunological homocostasis is disrupted by the introduction of substances which cannot be accommodated as self, a dynamic cellular interaction of the immune system ensues which may result in a positive state (immune response with subsequent memory) or in a negative one (immune unrcsponsiveness with subsequent tolerance) While much is known about both positive and negative states of immune function, relatively little work has focused upon the precise mechanisms of the decision-making process We have examined the potential roles of IL-1 in this process. Using a well defined helper T-cell clone (D10.G4 1) and antigen-pulsed splenic adherent cells we have found that a number of agents which block the induction or action of IL-1 (ultraviolet irradiation of APC. addition of cyclosponn A, addition of anti-L3T4 antibody) resulted in the production, by the clone, of an antigen-specific factor involved in the induction of a suppressor T-cell circuit This factor showed the same antigenic specificity as the helper cell (which is normally specific for antigen plus self la), and resembled by form and function a number of well characterized antigen-specific suppressor inducer molecules Crude preparations containing IL-1 prevented the appearance of this suppressor inducer factor These observations underline the pivotal role of the APC-hclpcr T-cell interaction in determining, in part, whether immunity or suppression will follow exposure to an antigen and thus, the immunorcgulatory outcome of an antigcnic challenge.
KW - Antigen-presenting cells
KW - Immunoregulation
KW - Interleukin-1
UR - http://www.scopus.com/inward/record.url?scp=84959744372&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/XXIV.suppl_1.105
DO - 10.1093/rheumatology/XXIV.suppl_1.105
M3 - Article
AN - SCOPUS:84959744372
SN - 1462-0324
VL - 24
SP - 105
EP - 111
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
ER -