Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications

Alfonso Enrique Martinez-Nunez, Christopher J. Rozell, Simon Little, Huiling Tan, Stephen L. Schmidt, Warren M. Grill, Miroslav Pajic, Dennis A. Turner, Coralie de Hemptinne, Andre Machado, Nicholas Schiff, Abbey S. Holt-Becker, Robert S. Raike, Mahsa Malekmohammadi, Yagna J. Pathak, Lyndahl Himes, David Greene, Lothar Krinke, Mattia Arlotti, Lorenzo RossiJacob Robinson, Bahne H. Bahners, Vladimir Litvak, Luka Milosevic, Saadi Ghatan, Frederic L.W.V.J. Schaper, Michael D. Fox, Nicholas M. Gregg, Cynthia Kubu, James J. Jordano, Nicola G. Cascella, Young Hoon Nho, Casey H. Halpern, Helen S. Mayberg, Ki Sueng Choi, Haneul Song, Jungho Cha, Sankar Alagapan, Nico U.F. Dosenbach, Evan M. Gordon, Jianxun Ren, Hesheng Liu, Lorraine V. Kalia, Dorian Kusyk, Adolfo Ramirez-Zamora, Kelly D. Foote, Michael S. Okun, Joshua K. Wong

Research output: Contribution to journalArticlepeer-review

Abstract

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson’s disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.

Original languageEnglish
Article number1544994
JournalFrontiers in Human Neuroscience
Volume19
DOIs
StatePublished - 2025

Keywords

  • Parkinson’s disease
  • deep brain stimulation
  • depression
  • epilepsy
  • neuromodulation
  • obsessive-compulsive disorder
  • sleep
  • stroke

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