Procedural Risk in Congenital Cardiac Catheterization (PREDIC3T)

Brian P. Quinn, Mary Yeh, Kimberlee Gauvreau, Fatima Ali, David Balzer, Oliver Barry, Sarosh Batlivala, Darren Berman, Susan Foerster, Bryan Goldstein, Michael Hainstock, Ralf Holzer, Dana Janssen, Michael L. O’byrne, Lauren Shirley, Sara Trucco, Wendy Whiteside, Lisa Bergersen

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16 Scopus citations


BACKGROUND: Advancements in the field, including novel procedures and multiple interventions, require an updated approach to accurately assess patient risk. This study aims to modernize patient hemodynamic and procedural risk classification through the creation of risk assessment tools to be used in congenital cardiac catheterization. METHODS AND RESULTS: Data were collected for all cases performed at sites participating in the C3PO (Congenital Cardiac Catheterization Project on Outcomes) multicenter registry. Between January 2014 and December 2017, 23 119 cases were recorded in 13 participating institutions, of which 88% of patients were <18 years of age and 25% <1 year of age; a highseverity adverse event occurred in 1193 (5.2%). Case types were defined by procedure(s) performed and grouped on the basis of association with the outcome, high-severity adverse event. Thirty-four unique case types were determined and stratified into 6 risk categories. Six hemodynamic indicator variables were empirically assessed, and a novel hemodynamic vulnerability score was determined by the frequency of high-severity adverse events. In a multivariable model, case-type risk category (odds ratios for category: 0=0.46, 1=1.00, 2=1.40, 3=2.68, 4=3.64, and 5=5.25; all P≤0.005) and hemodynamic vulnerability score (odds ratio for score: 0=1.00, 1=1.27, 2=1.89, and ≥3=2.03; all P≤0.006) remained independent predictors of patient risk. CONCLUSIONS: These case-type risk categories and the weighted hemodynamic vulnerability score both serve as independent predictors of patient risk for high-severity adverse events. This contemporary procedure-type risk metric and weighted hemodynamic vulnerability score will improve our understanding of patient and procedural outcomes.

Original languageEnglish
Article numbere022832
JournalJournal of the American Heart Association
Issue number1
StatePublished - Jan 4 2022


  • Comparative effectiveness/patient-centered outcomes research
  • Congenital heart disease
  • Pediatric intervention
  • Pediatrics


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