Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract

Keyphrases

• Mouse Model 100%
• CRYAB 100%
• Cataract 100%
• Changes in Gene Expression 100%
• Knock-in Mouse Model 50%
• RNA-seq Analysis 50%
• Autosomal Dominant 50%
• Histone H4 50%
• Histone H2B 50%
• Heterozygous mutant 50%
• Histone H2A 50%
• Lin Genes 50%
• Transcript Level 25%
• Gene Knockout 25%
• Gene Expression 25%
• Proteomic Analysis 25%
• Lens Transparency 25%
• Eye Lens 25%
• Oxidative Stress 25%
• Protein Aggregation 25%
• High Concentration 25%
• Crystallin 25%
• Postnatal Age 25%
• Transcriptional Changes 25%
• Early Postnatal 25%
• Refractive Index 25%
• Transcriptional Mechanism 25%
• Altered Expression 25%
• UV Exposure 25%
• Intracellular Water 25%
• Water Channel 25%
• Hereditary Cataract 25%
• Identified Genes 25%
• Long-lived Proteins 25%
• Cataract Formation 25%
• Destabilizing mutations 25%
• Glycation 25%
• Histone Expression 25%

Biochemistry, Genetics and Molecular Biology

• Gene Expression 100%
• Mouse Model 100%
• Autosomal Dominant Inheritance 100%
• Histone H4 100%
• RNA Sequencing 100%
• Histone H2B 100%
• Histone H2A 100%
• Proteomics 50%
• Gene Knockout 50%
• Oxidative Stress 50%
• Histone 50%
• Crystallin 50%
• Glycation 50%
• Protein Aggregation 50%
• Refraction Index 50%