TY - JOUR
T1 - Probable Cerebral Amyloid Angiopathy-Related Inflammation Associated With Sitravatinib
T2 - A Case Report
AU - Ray, Christopher
AU - Dionne, Kalen
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Background and ObjectivesWe present the case of a 67-year-old man who developed encephalopathy, headaches, and seizure activity after initiating treatment with the novel tyrosine kinase inhibitor, sitravatinib.MethodsThe patient was identified in routine clinical practice.ResultsBrain MRI revealed lobar microhemorrhages and bihemispheric vasogenic edema. The patient met the criteria for probable cerebral amyloid angiopathy-related inflammation (CAA-ri) and responded favorably to high-dose methylprednisolone.DiscussionThis report of neurologic autoimmunity in a patient receiving sitravatinib opens new lines of inquiry into the pathophysiology of CAA-ri. We emphasize the importance of early recognition and treatment of CAA-ri among patients receiving immunomodulatory chemotherapy.
AB - Background and ObjectivesWe present the case of a 67-year-old man who developed encephalopathy, headaches, and seizure activity after initiating treatment with the novel tyrosine kinase inhibitor, sitravatinib.MethodsThe patient was identified in routine clinical practice.ResultsBrain MRI revealed lobar microhemorrhages and bihemispheric vasogenic edema. The patient met the criteria for probable cerebral amyloid angiopathy-related inflammation (CAA-ri) and responded favorably to high-dose methylprednisolone.DiscussionThis report of neurologic autoimmunity in a patient receiving sitravatinib opens new lines of inquiry into the pathophysiology of CAA-ri. We emphasize the importance of early recognition and treatment of CAA-ri among patients receiving immunomodulatory chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85128900798&partnerID=8YFLogxK
U2 - 10.1212/CPJ.0000000000001162
DO - 10.1212/CPJ.0000000000001162
M3 - Article
C2 - 35747887
AN - SCOPUS:85128900798
SN - 2163-0402
VL - 12
SP - E4-E6
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 2
ER -