TY - JOUR
T1 - Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
AU - Muszynski, Jennifer A.
AU - Bembea, Melania M.
AU - Gehred, Alison
AU - Lyman, Elizabeth
AU - Cashen, Katherine
AU - Cheifetz, Ira M.
AU - Dalton, Heidi J.
AU - Himebauch, Adam S.
AU - Karam, Oliver
AU - Moynihan, Katie M.
AU - Nellis, Marianne E.
AU - Ozment, Caroline
AU - Raman, Lakshmi
AU - Rintoul, Natalie E.
AU - Said, Ahmed
AU - Saini, Arun
AU - Steiner, Marie E.
AU - Thiagarajan, Ravi R.
AU - Watt, Kevin
AU - Willems, Ariane
AU - Zantek, Nicole D.
AU - Barbaro, Ryan P.
AU - Steffen, Katherine
AU - Vogel, Adam M.
AU - Alexander, Peta M.A.
N1 - Publisher Copyright:
Copyright © 2024 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
PY - 2024/7/1
Y1 - 2024/7/1
N2 - OBJECTIVES: To identify and prioritize research questions for anticoagulation and hemostasis management of neonates and children supported with extracorporeal membrane oxygenation (ECMO) from the Pediatric ECMO Anticoagulation CollaborativE (PEACE) consensus. DATA SOURCES: Systematic review was performed using PubMed, EMBASE, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021, followed by serial consensus conferences of international, interprofessional experts in the management of ECMO for critically ill neonates and children. STUDY SELECTION: The management of ECMO anticoagulation for critically ill neonates and children. DATA EXTRACTION: Within each of the eight subgroups, two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts. DATA SYNTHESIS: Following the systematic review of MEDLINE, EMBASE, and Cochrane Library databases from January 1988 to May 2021, and the consensus process for clinical recommendations and consensus statements, PEACE panel experts constructed research priorities using the Child Health and Nutrition Research Initiative methodology. Twenty research topics were prioritized, falling within five domains (definitions and outcomes, therapeutics, anticoagulant monitoring, protocolized management, and impact of the ECMO circuit and its components on hemostasis). CONCLUSIONS: We present the research priorities identified by the PEACE expert panel after a systematic review of existing evidence informing clinical care of neonates and children managed with ECMO. More research is required within the five identified domains to ultimately inform and improve the care of this vulnerable population.
AB - OBJECTIVES: To identify and prioritize research questions for anticoagulation and hemostasis management of neonates and children supported with extracorporeal membrane oxygenation (ECMO) from the Pediatric ECMO Anticoagulation CollaborativE (PEACE) consensus. DATA SOURCES: Systematic review was performed using PubMed, EMBASE, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021, followed by serial consensus conferences of international, interprofessional experts in the management of ECMO for critically ill neonates and children. STUDY SELECTION: The management of ECMO anticoagulation for critically ill neonates and children. DATA EXTRACTION: Within each of the eight subgroups, two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts. DATA SYNTHESIS: Following the systematic review of MEDLINE, EMBASE, and Cochrane Library databases from January 1988 to May 2021, and the consensus process for clinical recommendations and consensus statements, PEACE panel experts constructed research priorities using the Child Health and Nutrition Research Initiative methodology. Twenty research topics were prioritized, falling within five domains (definitions and outcomes, therapeutics, anticoagulant monitoring, protocolized management, and impact of the ECMO circuit and its components on hemostasis). CONCLUSIONS: We present the research priorities identified by the PEACE expert panel after a systematic review of existing evidence informing clinical care of neonates and children managed with ECMO. More research is required within the five identified domains to ultimately inform and improve the care of this vulnerable population.
KW - anticoagulation
KW - blood transfusion
KW - extracorporeal membrane oxygenation
KW - hemolysis
KW - pediatrics
UR - http://www.scopus.com/inward/record.url?scp=85197533339&partnerID=8YFLogxK
U2 - 10.1097/PCC.0000000000003488
DO - 10.1097/PCC.0000000000003488
M3 - Article
C2 - 38959362
AN - SCOPUS:85197533339
SN - 1529-7535
VL - 25
SP - e78-e89
JO - Pediatric Critical Care Medicine
JF - Pediatric Critical Care Medicine
IS - 7
ER -